Rat Surgical Model
Rat Surgical Model - Related Videos
18:47
Surgical Procedures for a Rat Model of Partial Orthotopic Liver Transplantation with Hepatic Arterial Reconstruction
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Cited by 22 •
2013
Orthotopic liver transplantation in rats is an indispensable experimental model for biomedical research. Here we present our surgical procedures for orthotopic rat liver transplantation with hepatic arterial reconstruction using a 50% partial graft.
02:36
Generating a Glioblastoma Rat Model
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2025
Source: Bolcaen, J., et. al., PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator. J. Vis. Exp. (2017)This video demonstrates the procedure for establishing a glioblastoma rat model by stereotactically injecting brain tumor-causing glioblastoma cells into the prefrontal cortex.
08:18
A Model of Chronic Nutrient Infusion in the Rat
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Cited by 1 •
2013
A protocol for chronic infusions of glucose and Intralipid in rats is described. This model can be used to study the impact of nutrient excess on organ function and physiological parameters.
04:12
Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats
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Cited by 3 •
2025
Posthemorrhagic hydrocephalus of prematurity (PHHP) can be modeled in neonatal rats by combining chorioamnionitis and intraventricular hemorrhage. The combination of these prenatal and postnatal events accurately recapitulates the clinical hallmarks of PHHP, including macrocephaly, ventriculomegaly, and elevated intracranial pressure, through the lifespan.
09:39
Creation of Reversible Cholestatic Rat Model
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2011
Cholestasis is a clinical condition commonly encountered by both surgeons and gastroenterologists. Creation of a reversible cholestatic rat model can be challenging in view of the smaller size and unique hepatopancreatobiliary anatomy in rats. This video article demonstrates the creation of a reversible cholestatic model.
FAQs
The central mechanistic value lies in tracking responses across multiple levels of the organism. A controlled surgical change can produce local inflammation or tissue repair while also affecting immune activity elsewhere, allowing researchers to examine relationships among organs, immune cells, and infectious agents over time. This helps distinguish localized effects from broader systemic immune responses.
An intact rat preserves interactions among organs, immune cells, tissues, and infectious agents that may be difficult to assess separately. This integrated setting allows investigators to connect an anatomical or physiological change with pathogen-related outcomes and systemic immune activity. The resulting observations provide context for how infection, inflammation, and repair develop together within the organism.
Reproducibility depends on defining the condition being created, applying the operation consistently, and maintaining monitored laboratory protocols. Standardization reduces variation in the resulting physiological, pathological, or infectious state, making immune and tissue responses easier to compare across experiments. Consistent procedures also strengthen evaluations of potential interventions by improving confidence that differences reflect the intervention rather than uncontrolled model variation.
A typical workflow begins by selecting a defined physiological, pathological, or infectious condition, followed by a controlled operation or anatomical alteration intended to reproduce it. Researchers then monitor the animals under established laboratory protocols and examine responses over time. This sequence connects the initial surgical change with inflammation, tissue repair, pathogen-related outcomes, or systemic immune effects.
These models support examination of several connected outcomes, including inflammation, tissue repair, pathogen-related effects, and systemic immune responses. Observing these responses over time helps researchers determine how a surgical alteration influences both local tissues and the wider organism. Such information can clarify disease-related processes and identify measurable effects of potential interventions.
They are useful when an intervention must be evaluated within the coordinated environment of an intact organism. After researchers establish a standardized surgical condition, they can assess whether the intervention changes inflammation, pathogen-related outcomes, tissue repair, or systemic immune responses. This approach connects treatment effects to interactions among organs and immune defenses rather than examining a single response in isolation.