Autologous Tumor Model
Autologous Tumor Model - Related Videos
10:44
Modeling Intracerebral Hemorrhage in Mice: Injection of Autologous Blood or Bacterial Collagenase
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Cited by 60 •
2012
Clinically relevant animal models of intracerebral hemorrhage (ICH) are needed to extend our knowledge of hemorrhagic stroke and to examine novel therapeutic strategies. In this study, we describe and evaluate two ICH models that implement unilateral injections of either autologous whole blood or bacterial collagenase into the basal ganglia (corpus striatum) of mice.
09:41
Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage
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Cited by 35 •
2014
Preclinical models of intracerebral hemorrhage are utilized to mimic certain aspects of clinical disease. Thus, mechanisms of injury and potential therapeutic strategies may be explored. In this protocol, two models of intracerebral hemorrhage are described, intrastriatal (basal ganglia) injections of autologous blood or collagenase.
07:02
Autologous Blood Injection to Model Spontaneous Intracerebral Hemorrhage in Mice
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Cited by 28 •
2011
The autologous blood injection model of intracerebral hemorrhage in mice described in this protocol uses the double injection technique to minimize risk of blood reflux up the needle track, no anticoagulants in the pumping system, and eliminates all dead space and expandable tubing in the system.
11:49
Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model
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Cited by 12 •
2011
A method for seeding titanium blood-contacting biomaterials with autologous cells and testing biocompatibility is described. This method uses endothelial progenitor cells and titanium tubes, seeded within minutes of surgical implantation into porcine venae cavae. This technique is adaptable to many other implantable biomedical devices.
08:58
Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model
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Cited by 5 •
2013
An experimental technique for the treatment of chondral defects in the rabbit's knee joint is described. The implantation of autologous chondrocytes seeded on a matrix is a well-accepted method for the remodeling and repair of articular cartilage lesions providing satisfying long-term results. Matrix-assisted autologous chondrocyte transplantation (MACT) offers a standardized and clinically established implantation method.
FAQs
Its value depends on retaining important genetic and phenotypic features from the source tumor while the material is maintained for study. This continuity allows researchers to examine tumor behavior in relation to the original patient’s disease rather than relying only on generalized cancer characteristics, strengthening the biological relevance of experimental findings.
Tumor behavior reflects interactions with the surrounding microenvironment, so those interactions can influence growth, treatment response, and resistance. Including this context helps researchers evaluate how a patient-derived cancer behaves beyond its isolated tumor cells. Findings may therefore reveal response patterns that are not apparent from testing tumor characteristics alone.
The source material may be maintained by expanding tumor cells in culture or by implanting the tumor into an experimental host. These approaches provide different settings for examining the cancer while retaining relevant features of the original tissue. The selected format determines how researchers investigate growth, treatment response, and associated biological interactions.
Researchers first collect tumor tissue or cells from an individual patient and then maintain the material for experimental study. Maintenance may involve expansion in culture or implantation into an experimental host. Throughout this process, preserving key genetic and phenotypic features is important because those features connect the model’s behavior to the source patient’s disease.
Researchers use these models to assess how a patient-specific cancer grows and responds to treatment before drawing conclusions about therapeutic performance. Because experimental observations can be linked to the source patient’s disease, the approach supports preclinical drug evaluation with clinically relevant context and can help investigate treatment resistance alongside initial response.
The model connects experimental results with the disease from which the tumor material originated. By examining growth, treatment response, resistance, and microenvironmental interactions in that patient-specific setting, researchers can generate evidence that may inform more individualized treatment strategies. Its contribution is strongest when laboratory observations remain linked to the source cancer’s biology.