Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Markus T. Berninger; Gabriele Wexel; Ernst J. Rummeny; Andreas B. Imhoff; Martina Anton; Tobias D. Henning; Stephan Vogt

doi:10.3791/4422

Journal

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Medicine

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Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

JoVE Journal
Medicine

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JoVE Journal Medicine

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

14,265 Views

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08:58 min

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May 21, 2013

DOI:

10.3791/4422-v

DOI:

10.3791/4422-v

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08:58 min

May 21, 2013

•

6 Views

Markus T. Berninger^1,2, Gabriele Wexel³, Ernst J. Rummeny², Andreas B. Imhoff¹, Martina Anton³, Tobias D. Henning*^2,4, Stephan Vogt*¹

¹Department of Orthopaedic Sports Medicine,Klinikum rechts der Isar der Technischen Universität München, ²Department of Radiology,Klinikum rechts der Isar der Technischen Universität München, ³Institute of Experimental Oncology and Therapy Research,Klinikum rechts der Isar der Technischen Universität München, ⁴Department of Radiology,Uniklinik Köln

Summary

An experimental technique for the treatment of chondral defects in the rabbit's knee joint is described. The implantation of autologous chondrocytes seeded on a matrix is a well-accepted method for the remodeling and repair of articular cartilage lesions providing satisfying long-term results. Matrix-assisted autologous chondrocyte transplantation (MACT) offers a standardized and clinically established implantation method.