Disease-modifying Antirheumatic

Disease-modifying antirheumatic drugs (DMARDs) are medicines that target the underlying immune and inflammatory processes driving rheumatic diseases, helping prevent lasting joint and tissue damage rather than only relieving pain. They work through different mechanisms, including suppressing inflammatory signaling, reducing immune-cell activity, or altering specific molecular pathways involved in autoimmunity; conventional, biologic, and targeted synthetic DMARDs represent major treatment groups. Clinicians use these therapies to manage conditions such as rheumatoid arthritis and other inflammatory arthritides, often monitoring treatment response and adverse effects over time. By limiting disease progression, DMARDs can preserve function, reduce disability, and improve long-term outcomes.

Disease-modifying Antirheumatic - Related Videos

Research

JoVE Journal - Medicine

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

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Cited by 5 •

2016

A reverse-genetics approach to understanding gene families associated with human disease is presented, using mouse as a model system, and the subsequent mouse phenotyping schedule is described. Because mice defective in a gene of interest, HtrA2, manifested Parkinsonian symptoms, the phenotyping regimen is focused on identifying neurological defects.

A Modified Precipitation Method to Isolate Urinary Exosomes

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Cited by 32 •

2015

This manuscript describes a protocol for isolating exosomes from human urine using a modified precipitation technique.

Education

JoVE Science Education - Environmental Sciences

Testing For Genetically Modified Foods

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2023

Source: Laboratories of Margaret Workman and Kimberly Frye - Depaul University Genetic modification of foods has been a controversial issue due to debated concerns over health and environmental safety. This experiment demonstrates technical understanding of how food DNA is genetically identified, allowing for educated decision making about the safety and potential dangers of using genetically modified organisms (GMOs) in food supplies. Polymerase Chain Reaction (PCR) is used to amplify food DNA...

Modified Radical Neck Dissection for Cervical Metastasis

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2026

Here, we present a protocol for radical neck dissection integrating oncologic resection, cranial nerve preservation, and functional reconstruction in cervical metastasis.

Preventing the Spread of Malaria and Dengue Fever Using Genetically Modified Mosquitoes

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Cited by 10 •

2007

In this candid interview, Anthony A. James explains how mosquito genetics can be exploited to control malaria and dengue transmission. Population replacement strategy, the idea that transgenic mosquitoes can be released into the wild to control disease transmission, is introduced as well as the concept of genetic drive and the design criterion for an effective genetic drive system. The ethical considerations of releasing genetically-modified organisms into the wild are also discussed.

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