Neurological Score

A neurological score is a standardized numerical measure used to describe a person’s neurological function and detect changes over time. Clinicians assign points to observed findings such as level of consciousness, orientation, motor responses, sensation, speech, and reflexes, following defined examination criteria; the resulting total or subscore profile summarizes the patient’s condition. In medicine, neurological scores support rapid assessment, communication among healthcare teams, monitoring after injury or illness, and evaluation of treatment response. They also provide structured outcomes for clinical research, although scores complement rather than replace a complete neurological examination and clinical judgment.

Neurological Score - Related Videos

Research

JoVE Journal - Medicine

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS

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Cited by 120 •

2015

This video protocol describes a sensitive, reliable, and quick method for evaluating the neuromuscular deficits in a transgenic mouse model of amyotrophic lateral sclerosis.

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

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Cited by 21 •

2016

An optimized testing protocol is presented in this paper for the Rotarod performance test, used for measuring progressive neurological disability in TMEV-infected mice.

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies

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2025

This article presents a protocol for executing the highly translational and independently proven mouse Stroke Unit (mSU) concept in large-stroke mice. It also provides a standardized protocol for executing the focal experimental stroke scale in mice, which evaluates stroke focal deficits detected even long-term.

A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia

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Cited by 415 •

2010

We describe a protocol for the rapid and sensitive quantification of disease severity in mouse models of cerebellar ataxia. Measures include hind limb clasping, ledge test, gait and kyphosis. This protocol effectively discriminates between affected and non-affected individuals, and detects the progression of affected individuals over time.

Lipidomics and Transcriptomics in Neurological Diseases

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Cited by 13 •

2022

This article presents a modular protocol for tissue lipidomics and transcriptomics, and plasma lipidomics in neurological disease mouse models targeting lipids underlying inflammation and neuronal activity, membrane lipids, downstream messengers, and mRNA-encoding enzymes/receptors underlying lipid function. Sampling, sample processing, extraction, and quantification procedures are outlined.

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