Percutaneous Lung Biopsy
Percutaneous Lung Biopsy - Related Videos
11:27
Preparation and Respirometric Assessment of Mitochondria Isolated from Skeletal Muscle Tissue Obtained by Percutaneous Needle Biopsy
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Cited by 24 •
2015
Methods for biopsy of Vastus lateralis, preparation of purified mitochondria, and respirometric profiling are described. The use of small muscle volume makes this technique suitable for clinical research applications.
08:20
Percutaneous Cricothyrotomy
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2023
Source: James W Bonz, MD, Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA A surgical airway procedure is indicated when other forms of endotracheal intubation have failed and ventilation is worsening or not possible. This is the feared "can't intubate, can't ventilate" scenario, and in the emergency setting, cricothyrotomy is the surgical procedure of choice. Cricothyrotomy is preferred over tracheotomy because of the lower risk of complications, the predictable anatomy...
06:03
Use of Electromagnetic Navigational Transthoracic Needle Aspiration (E-TTNA) for Sampling of Lung Nodules
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Cited by 12 •
2015
We describe the novel use of electromagnetic navigational guided transthoracic needle aspiration for the pathologic assessment of human lung nodules.
09:31
In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
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Cited by 10 •
2015
Optical coherence tomography (OCT) is a high resolution imaging technique that allows analysis of tissue specific optical properties providing the means for tissue differentiation. We developed needle based OCT, providing real-time imaging combined with on-the-spot tumor differentiation. This publication describes a method for percutaneous, needle based OCT of renal masses.
08:49
Exosomal miRNA Analysis in Non-small Cell Lung Cancer (NSCLC) Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool
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Cited by 59 •
2016
This protocol describes the feasibility to perform miRNA profiling in exosomes, released in plasma of NSCLC patients, through a commercial exosome isolation kit with Proteinase K and RNAse treatments, in order to avoid circulating miRNAs contamination and evaluate their biomarker features in NSCLC.
FAQs
Computed tomography or another imaging method helps the clinician identify the target lesion and track the needle as it advances through the chest wall. Patient-controlled breathing can further support accurate positioning by helping maintain a consistent relationship between the lesion and the needle. Together, these measures improve the likelihood that the collected tissue represents the pulmonary abnormality being evaluated.
Imaging may show that an abnormality exists but may not establish its underlying cause. Pathological analysis examines the collected tissue to distinguish malignancy, infection, inflammation, or other disease processes. When needed, molecular analysis adds further information about the lesion. These results can convert an uncertain imaging finding into a diagnosis that supports more appropriate treatment planning.
Percutaneous lung biopsy can provide diagnostic tissue while avoiding the need for a surgical biopsy in appropriate cases. Its minimally invasive nature may make it a useful alternative when imaging alone is insufficient, but it does not eliminate procedural risk. Pneumothorax and bleeding remain important possible complications, so the potential diagnostic benefit must be considered alongside monitoring requirements.
The clinician first uses computed tomography or another imaging method to locate and target the pulmonary lesion. A biopsy needle is then advanced through the skin and chest wall into the abnormality, with imaging supporting its position. The tissue sample is collected for pathological evaluation and, when indicated, molecular analysis. Monitoring follows because pneumothorax and bleeding can occur.
Breathing changes the position of structures within the chest, which can affect the relationship between the needle and the targeted lesion. During a percutaneous lung biopsy, the patient may control breathing to support more accurate needle positioning. This coordination is particularly relevant when the clinician is advancing the needle under imaging guidance and seeking representative tissue from a specific abnormality.
The approach is useful when imaging identifies a pulmonary abnormality but cannot by itself determine whether the process is malignant, infectious, inflammatory, or another type of disease. Tissue results can provide a definitive diagnosis and help guide treatment selection. It is therefore relevant to diagnostic decision-making in medicine when a less invasive tissue-sampling option can replace the need for surgical biopsy.