Awake Behaving Monkey
Awake Behaving Monkey - Related Videos
09:46
A Pressure Injection System for Investigating the Neuropharmacology of Information Processing in Awake Behaving Macaque Monkey Cortex
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Cited by 3 •
2016
Here, we show the pressure injection of neuropharmacological substances during single-cell recording in an awake, behaving macaque monkey. This procedure allows pharmacological manipulation in the direct vicinity of a cortical recording site.
10:44
Construction of Microdrive Arrays for Chronic Neural Recordings in Awake Behaving Mice
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Cited by 30 •
2013
The design and assembly of microdrives for in vivo electrophysiological recordings of brain signals from the mouse is described. By attaching microelectrode bundles to sturdy driveable carriers, these techniques allow for long-term and stable neural recordings. The lightweight design allows for unrestricted behavioral performance by the animal following drive implantation.
09:42
Injections of AAV Vectors for Optogenetics in Anesthetized and Awake Behaving Non-Human Primate Brain
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Cited by 4 •
2021
As currently implemented, optogenetics in non-human primates requires injection of viral vectors into the brain. An optimal injection method should be reliable and, for many applications, capable of targeting individual sites of arbitrary depth that are readily and unambiguously identified in postmortem histology. An injection method with these properties is presented.
08:07
Batch Immunostaining for Large-Scale Protein Detection in the Whole Monkey Brain
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Cited by 5 •
2009
Large-scale immunodetection of target proteins across the entire primate brain is possible by employing novel tissue embedding and sectioning methods combined with the use of creative apparatus for batch staining of multiple free-floating sections at a given time.
10:58
A Procedure for Implanting Organized Arrays of Microwires for Single-unit Recordings in Awake, Behaving Animals
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Cited by 7 •
2014
Implanting organized arrays of microwires for use in single-unit electrophysiological recordings presents a number of technical challenges. Methods for performing this technique and the equipment necessary are described. Also, the beneficial use of organized microwire arrays to record from distinct neural subregions with high spatial selectivity is discussed.
FAQs
The awake state preserves interactions among cognition, sensory processing, motor control, and behavior that anesthesia can disrupt. This allows researchers to examine brain and body function while the animal perceives stimuli, makes decisions, or produces movements. The resulting measurements are therefore more closely tied to active behavioral performance than observations obtained under anesthesia.
Researchers compare behavioral measurements with neural recording, stimulation, eye tracking, or imaging collected during controlled tasks. This coordination helps reveal how activity changes when the monkey processes sensory information, selects a response, or moves. Linking these signals provides a way to relate observable performance to underlying brain and body function rather than examining either domain in isolation.
Controlled tasks can be designed to examine learning, attention, decision-making, sensory processing, and movement. Researchers observe how performance changes as the monkey encounters stimuli, makes choices, or produces actions, then relate those changes to recorded or manipulated activity. This makes the approach useful for studying interactions among cognitive processes, perception, and motor behavior.
A study may pair task performance with neural recording, stimulation, eye tracking, or imaging. Each method contributes a different view of the same active episode: behavior shows the task outcome, eye tracking can characterize visual behavior, and neural or imaging methods assess activity. Stimulation can further examine how altering activity relates to observed performance.
Researchers first have the monkey perform a controlled task while it remains conscious and behaviorally engaged. They then collect behavioral measurements together with one or more complementary methods, such as neural recording, stimulation, eye tracking, or imaging. Analysis focuses on how measured activity changes alongside perception, decisions, movements, or task performance.
They are useful when the research question depends on interactions between active behavior and brain function. Applications include investigations of learning, attention, decision-making, sensory processing, and movement. Because the approach preserves cognition and action during task performance, it can connect behavioral outcomes with neural activity in ways that are difficult to capture when anesthesia disrupts those interactions.
The approach gives researchers a behavioral context for examining brain activity and movement while tasks are performed. That context supports neuroengineering studies concerned with relationships between neural signals and behavior, as well as investigations of neurological disorders. Comparing activity with perception, decisions, or movements can help characterize how altered brain function relates to observable performance.