Brain Herniation

Brain herniation is the displacement of brain tissue from its normal compartment when increased intracranial pressure forces it through rigid anatomical openings or across brain partitions. Swelling, bleeding, tumors, or blocked cerebrospinal fluid can raise pressure, compressing the brainstem, blood vessels, and cranial nerves as tissue shifts through structures such as the tentorial notch or foramen magnum. This life-threatening process can impair consciousness, breathing, pupil responses, and blood flow, making rapid recognition essential in neurology and emergency medicine. Studying brain herniation helps explain how intracranial pressure causes neurological deterioration and guides imaging, monitoring, and urgent treatment.

Brain Herniation - Related Videos

Research

JoVE EoE - Neurotherapeutics

Full-Endoscopic Isolation Zone Technique for the Treatment of Lumbar Disc Herniation

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2025

Source: Wang, L., et.al. Full-Endoscopic Isolation Zone Technique for the Treatment of Lumbar Disc Herniation. J. Vis. Exp.(2023)This video demonstrates a minimally invasive endoscopic procedure to treat lumbar disc herniation by removing the protruded nucleus pulposus and ruptured annulus fibrosus. The technique decompresses the affected nerve root, alleviates pain, and restores nerve function through targeted tissue resection and radiofrequency modulation.

Full-Endoscopic Isolation Zone Technique for the Treatment of Lumbar Disc Herniation

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Cited by 1 •

2023

Here, we present a protocol for the "isolation zone" technique in the treatment of lumbar disc herniation (LDH) under full-endoscopic spine surgery (FESS), including intervertebral foramen formation, targeted catheterization, nucleus pulposus resection, and annulus fibrosus formation, which together completely block the pain from the nerve conduction pathway.

Education

JoVE Core - Pathophysiology

Herniated Intervertebral Disc l: Introduction

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2026

Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...

Research

JoVE Journal - Neuroscience
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Lateral Fluid Percussion: Model of Traumatic Brain Injury in Mice

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Cited by 125 •

2011

Lateral fluid percussion (LFP), an established model of traumatic brain injury in mice, is demonstrated. LFP fulfills three major criteria for animal models: validity, reliability and clinical relevance. The procedure, consisting of surgical craniotomy, fixation of hub followed by induction of injury, resulting in focal and diffuse injuries, is described.

A Mobile Outside-in Technique of Transforaminal Lumbar Endoscopy for Lumbar Disc Herniations

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Cited by 42 •

2018

Here we present a protocol of a novel outside-in technique of transforaminal endoscopic discectomy for lumbar disc herniations. The technical aspects of the technique, the wide indications of use, and the results of the treatment in 184 patients are described in detail.

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