Calcitonin Function
Calcitonin Function - Related Videos
00:51
Synthesis and Functions of Calcitonin
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2025
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin. The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
08:39
Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents
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Cited by 4 •
2022
The present protocol describes the ex vivo calcitonin gene-related peptide (CGRP) release model and the strategy to quantify the effect of pharmacological agents on the amount of CGRP released from the trigeminovascular system in rodents.
07:28
Visualizing the Calcitonin Gene-Related Peptide Immunoreactive Innervation of the Rat Cranial Dura Mater with Immunofluorescence and Neural Tracing
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Cited by 3 •
2021
Here we present a protocol to visualize spatial correlation of calcitonin gene-related peptide (CGRP)-immunoreactive nerve fibers and blood vessels in the cranial dura mater using immunofluorescence and fluorescent histochemistry with CGRP and phalloidin, respectively. In addition, the origin of these nerve fibers was retrograde traced with a fluorescent neural tracer.
02:45
Functional Groups
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2020
Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...
07:31
A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills
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Cited by 9 •
2020
This training protocol uses computerized training to teach technology-related everyday functional skills. These skills include financial skills, travel and transit, as well as medication management.
FAQs
A rise in blood calcium acts as the relevant physiological signal for calcitonin release. The resulting response combines reduced osteoclast-mediated bone resorption with increased calcium loss through the kidneys. Considering these actions together is important because they address calcium excess through both skeletal and renal pathways rather than through a single tissue.
Within bone remodeling, calcitonin function is most directly linked to suppression of osteoclast-mediated resorption. This limits the process by which bone mineral is released into the circulation when osteoclast activity is involved. Consequently, calcitonin is relevant not only to immediate calcium regulation but also to biological discussions of bone loss.
Calcitonin's renal effect contributes a separate route for lowering circulating calcium: the kidneys allow greater calcium loss when the hormone is released. This complements its action on bone and helps explain why calcitonin function is discussed in the broader context of mineral homeostasis, which includes coordinated control of calcium and phosphate balance.
Studying calcitonin function alongside parathyroid hormone helps place each hormone within the wider network that regulates calcium. The source context specifically identifies this relationship as useful for understanding calcium-regulating disorders. This comparison is therefore valuable when biology or medicine examines why calcium balance has shifted, rather than evaluating calcitonin as an isolated signal.
In medicine, calcitonin function is especially relevant when elevated calcium is part of the clinical problem. The overview supports its use in selected conditions involving elevated calcium, so its significance is practical as well as biological. The key outcome of this application is attention to a hormone that can lower calcium through skeletal and renal effects.
Calcitonin also has context in selected conditions involving bone loss. Its importance here follows from the connection between osteoclast-mediated resorption and bone remodeling. Studying the hormone can therefore link a molecular regulator of calcium balance with a broader skeletal outcome, while keeping bone remodeling and mineral regulation within the same biological framework.