Oxidative Fibers

Oxidative fibers are skeletal muscle fibers specialized for sustained, aerobic activity and resistance to fatigue. They generate ATP primarily through mitochondrial oxidative phosphorylation, supported by high mitochondrial density, abundant capillaries, and elevated myoglobin that improves oxygen delivery and storage; these features give the fibers their characteristic red appearance. Oxidative fibers contribute to posture, endurance exercise, and prolonged locomotion, while their function and distribution provide insight into muscle performance, metabolism, and adaptation. Studying these fibers helps biologists understand how training, aging, disease, and changes in energy demand remodel skeletal muscle.

Oxidative Fibers - Related Videos

Research

JoVE Journal - Biology

Respirometric Oxidative Phosphorylation Assessment in Saponin-permeabilized Cardiac Fibers

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Cited by 32 •

2011

Saponin-permeabilized fiber preparation in conjunction with respirometric oxidative phosphorylation analysis provides integrative assessment of mitochondrial function. Mitochondrial respiration in physiological and pathological states can reflect various regulatory influences including mitochondrial interactions, morphology and biochemistry.

Education

JoVE Core - Biology

Classification of Skeletal Muscle Fibers

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2019

Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions. Slow-Twitch Muscle Fibers Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...

Microfluidic Dry-spinning and Characterization of Regenerated Silk Fibroin Fibers

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Cited by 6 •

2017

A protocol for the microfluidic spinning and microstructure characterization of regenerated silk fibroin monofilament is presented.

Oxidation Numbers

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2020

In redox reactions, the transfer of electrons occurs between reacting species. Electron transfer is described by a hypothetical number called the oxidation number (or oxidation state). It represents the effective charge of an atom or element, which is assigned using a set of rules. Oxidation Number (Oxidation State) In the case of an ionic compound, oxidation numbers are assigned based on the number of electrons transferred between reacting species. For example, in the formation of calcium...

In Vivo Single-Fiber Recording of Sciatic Nerve C-Fibers in Rats

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2025

This video demonstrates a single-fiber recording of C-fiber nerve conduction in rats. An anesthetized rat is incised to expose the sciatic nerve, which provides sensory and motor supply to the lower limbs. The individual C-fibers are then exposed. Electrical stimulation is provided using stimulus electrodes implanted in the foot, and a response is recorded from a single nerve fiber.

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