Gamma Priors

Gamma priors are probability distributions used in Bayesian inference to represent prior uncertainty about positive-valued parameters, such as rates, intensities, and precisions. Defined by shape and rate, or shape and scale, parameters, they assign density only to positive values; their conjugacy with Poisson likelihoods allows prior and observed count information to combine through updated shape and rate parameters, producing a gamma posterior. In engineering, this framework supports reliability analysis, failure-rate estimation, queueing models, signal and system modeling, and uncertainty quantification, while prior parameters can encode historical data or expert knowledge and the posterior can guide prediction and risk-informed decisions.

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Research

JoVE EoE - Neurotherapeutics

Evoked Gamma Oscillations for the Treatment of Alzheimer’s Disease

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2025

Begin with a patient diagnosed with Alzheimer’s disease, wearing a gamma therapy stimulation device.The device consists of an eye-set and headphones.Using the controller, activate the device to deliver auditory and visual stimulation.The visual component emits flickering light at a gamma frequency, while the auditory component produces synchronized sound pulses.Gamma oscillations are brain waves generated by synchronized neuronal firing, crucial for cognition and memory.In AD, these...

Intravital Visualization of Gamma Delta Intraepithelial Lymphocytes

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2025

This video demonstrates the visualization of γδ intraepithelial lymphocytes (IELs) in transgenic mice using confocal microscopy. The surgical procedure involves creating a perforation line and making a longitudinal incision to expose the intestinal mucosa and villi. The transgenic mice express reporter proteins exclusively in γδ IELs, allowing their tracking. Intravital imaging captures the dynamic movement of green fluorescence-labeled γδ IELs along the intestinal epithelial cell's basement...

Recording Gamma Band Oscillations in Pedunculopontine Nucleus Neurons

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Cited by 3 •

2016

The pedunculopontine nucleus (PPN) is located in the brainstem and its neurons are maximally activated during waking and rapid eye movement (REM) sleep brain states. This work describes the experimental approach to record in vitro gamma band subthreshold membrane oscillation in PPN neurons.

Isolation and Flow Cytometric Analysis of Human Endocervical Gamma Delta T Cells

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Cited by 5 •

2017

We describe here an isolation method to obtain human endocervical intraepithelial lymphocytes for the analysis of intraepithelial gamma delta T cells. This protocol can be extended for the purification of endocervical gamma delta T cells by magnetic beads or by cell sorting.

Recording Gamma Band Oscillations From Pedunculopontine Nucleus Neurons in a Brain Slice

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2025

The video demonstrates the method to record gamma-band oscillations in PPN neurons. Using a sagittal brain section with synaptic blockers in aCSF, it employs positive current pulses via a patch pipette to open calcium channels, inducing crucial subthreshold activity for wakefulness.

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