Human Skin Transplant
Human Skin Transplant - Related Videos
07:59
Murine Full-thickness Skin Transplantation
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Cited by 41 •
2017
Murine full-thickness skin transplantation is a well-established model to study rejection in an alloimmune setting. Here, we provide a tutorial of each step involved in performing a BALB/c-->C57BL/6 full-thickness skin transplant.
06:42
Murine Skin Transplantation
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Cited by 36 •
2008
Allogeneic skin transplantation is a standard model to assay host T cell responses to MHC-disparate donor antigens. This video-article provides a visual tutorial of each step involved in performing a BALB/c-->C57BL/6 skin transplant.
06:48
Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice
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Cited by 10 •
2014
Tail-skin transplantation is a powerful model for studying T cell-dependent rejection and tolerance induction during allogeneic immune responses in mice. The advantages of this protocol are minor invasive surgery, and ease of monitoring with no need to sacrifice the recipient mouse.
04:07
Generation of Organotypic Full Skin Reconstructs: A Procedure to Establish 3D Skin Model Using Human Skin Samples
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2023
This video describes the detailed protocol for generating in vitro 3D organotypic skin reconstructs to study melanoma progression. This skin model mimics both the architecture and multicellular complexity of organs in vivo.
02:17
Transplantation of Human Neural Progenitor Cells in the Mouse Brain
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2025
Source: Weber, R. Z., et al. Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain. J. Vis. Exp. (2022)This video demonstrates the stereotaxic transplantation of genetically modified human neural progenitor cells (NPCs) into the mouse brain. Researchers inject NPCs expressing luciferase and fluorescent proteins, enabling in vivo bioluminescence imaging and post-mortem fluorescence microscopy to study cell survival, migration, and...
FAQs
Rejection begins when the recipient’s immune system identifies donor antigens as nonself. Immune cells and antibodies then target the transplanted tissue, creating an immune barrier to graft persistence. This response explains why an allograft can fail even when it initially covers the wound, and why compatibility and immune control are central to transplant outcomes.
Because the transferred tissue comes from the same patient, its antigens are not treated as foreign by that patient’s immune system. An allograft presents donor antigens from another person, so immune cells and antibodies may attack it. The contrast makes graft origin a primary variable when evaluating rejection risk and expected persistence.
Immunosuppressive treatment can reduce the immune response directed against donor tissue, improving the chance that an allograft will remain viable. However, suppressing immune activity also weakens protection against infection. In skin transplantation, this tradeoff requires researchers and clinicians to consider rejection control alongside the patient’s ability to defend against infectious threats.
Survival depends on several interacting conditions: adequate blood supply, immune compatibility, infection control, and integration with the wound bed. These factors determine whether the graft can persist rather than merely cover the defect temporarily. Assessing them connects the surgical result with both local wound biology and systemic immune behavior.
An injured area has lost part of its protective barrier, while a transplanted graft must integrate with the wound bed. Infection control therefore supports healing and helps protect graft survival. The concern becomes greater when immunosuppressive treatment is used, because reducing rejection also increases infection risk, linking local wound management with systemic host defense.
Skin transplantation may be considered after extensive burns, traumatic injuries, ulcers, or reconstructive procedures. In these settings, the goal extends beyond closing a wound: restoring barrier function and supporting healing are important outcomes. The range of indications also makes the approach relevant to both tissue repair and studies of how injured hosts respond to transplanted tissue.
It provides a clinically relevant setting for examining how host tissues recognize donor antigens, how immune cells and antibodies contribute to rejection, and how infection risk changes when immune activity is suppressed. Because graft survival also depends on wound-bed integration and blood supply, the model connects transplant immunology with barrier restoration and host defense.