Growth Plate Repair

Growth plate repair refers to medical strategies that restore or preserve the function of the growth plate, a region of cartilage responsible for lengthwise bone growth in children and adolescents. Injury can produce a physeal bar, in which bone bridges the damaged cartilage and disrupts continued growth; treatment may involve removing the bar, correcting deformity, or using regenerative approaches to support cartilage replacement. These interventions aim to reduce limb-length differences and angular deformities while preserving skeletal development. Research in orthopedics and tissue engineering continues to investigate how cells, biomaterials, and growth-regulating signals can improve repair outcomes.

Growth Plate Repair - Related Videos

Research

JoVE Journal - Medicine

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies

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Cited by 22 •

2017

The growth plate is a cartilaginous region in children's long bones where longitudinal growth occurs. When injured, bony tissue can form and impair growth. We describe a rat model of growth plate injury that leads to bony repair tissue, allowing the study of repair mechanisms and growth plate regeneration strategies.

Research

JoVE Journal - Medicine
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Tricolor Transgenic Murine Model for Studying Growth Plate Injury

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Cited by 2 •

2024

This protocol describes an improved mouse model for adolescent bone growth plate injuries. Using transgenic mice with tri-lineage fluorescent reporters for collagen types I, II, and X, the primary matrices associated with three different substrata of the growth plate, injury placement is guided by native fluorescence under the microscope.

Solubilization and Bio-conjugation of Quantum Dots and Bacterial Toxicity Assays by Growth Curve and Plate Count

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Cited by 7 •

2012

Nanoparticles such as semiconductor quantum dots (QDs) can be used to create photoactivatable agents for anti-microbial or anti-cancer applications. This technique shows how to water-solubilize cadmium telluride (CdTe) QDs, conjugate them to an antibiotic, and perform a bacterial inhibition assay based upon growth curves and plate count.

Education

JoVE Core - Molecular Biology
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Overview of DNA Repair

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2020

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage. Chemically...

Education

JoVE Core - Molecular Biology
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Base Excision Repair

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2020

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template. The first step of...

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