Pediatric Swine
Pediatric Swine - Related Videos
05:18
Implantation of Left Ventricular Assist Device (LVAD) in Juvenile Landrace Swine: A LVAD Implantation Model of Pediatric Heart Failure
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2026
This article presents a protocol to implant the left ventricular assist device (LVAD) into a piglet. This model represents a potent way to study the LVAD implantation in children and reveal the mechanism of ventricular reverse remodeling in LVAD treatment.
05:59
Nasal Wipes for Influenza A Virus Detection and Isolation from Swine
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Cited by 19 •
2015
The authors present a protocol to collect swine nasal wipes to detect and isolate influenza A viruses.
03:37
Evaluating the Effects of Different Polishing Methods on Color Stability of Dental Restorations in Pediatric Dentistry
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Cited by 1 •
2025
Here, we evaluated the impact of various polishing methods on the color stability of compomer and composite resin restorations used in anterior restorations within pediatric dentistry. This study highlights the significance of selecting appropriate polishing methods to enhance the color stability of compomer and composite resin restorations in pediatric dentistry.
11:19
Guidelines for Elective Pediatric Fiberoptic Intubation
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Cited by 17 •
2011
We describe guidelines to perform a safe and efficient elective fiberoptic intubation in pediatric patients while maintaining spontaneous ventilation.
04:27
Co-culturing Glutamatergic Neurons and Pediatric High-Grade Glioma Cells
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2025
This video showcases a technique for co-culturing glutamatergic neurons and pediatric high-grade glioma (pHGG) cells within a microfluidic device. Human induced pluripotent stem cells are introduced into the microfluidic system and incubated to promote their differentiation into mature cortical glutamatergic neurons. Following this, the pHGG cells are introduced onto the mature neurons, establishing a co-culture and enabling interactions between neurons and pHGG cells.
FAQs
Age-related organ maturation can change how an animal responds to injury, surgery, drugs, nutrition, or an implanted device. Studying animals at different developmental stages helps researchers examine whether a treatment’s effects depend on early-life physiology. This context is especially important when evaluating therapies intended for neonatal or childhood patients.
Maturing organ systems provide a biological basis for observing developmental differences in treatment responses. A procedure, medication, nutritional intervention, or device may produce different findings depending on the animal’s stage of development. Accounting for this variation helps researchers interpret safety and performance results more carefully before considering relevance to pediatric medicine.
Pediatric swine can reflect important features of pediatric anatomy and physiology, but they are not identical to human patients. Species-specific differences may affect how researchers interpret responses to disease, injury, surgery, drugs, or devices. Consequently, model findings can inform clinical development without automatically predicting human outcomes.
These models allow researchers to examine how early-life growth and organ maturation relate to disease responses and medical interventions under controlled conditions. The resulting observations can connect developmental biology with treatment safety, showing how age-related physiology may influence the effects of surgery, drugs, nutrition, or implanted technologies.
The model supports assessment of neonatal and childhood therapies, surgical techniques, and medical technologies. Researchers can examine these interventions in relation to growth, disease, injury, or developmental stage. This range makes pediatric swine useful when a study requires controlled evaluation of both treatment effects and age-dependent physiological responses.
A study first links the animal’s developmental stage to the medical question, then evaluates the selected intervention under controlled conditions. Researchers may examine responses involving injury, surgery, drugs, nutrition, or implanted devices, depending on the objective. Findings are subsequently interpreted in light of maturation and species-specific limitations.
They are most relevant when researchers need preclinical information for neonatal or childhood care and when developmental physiology may affect safety or performance. Applications include studying surgical approaches, therapies, and medical technologies before clinical use. Their contribution is strongest when investigators clearly account for maturation and cautious translation to humans.