Binge Drinking
Binge Drinking - Related Videos
01:23
Binge Eating Disorders
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2025
Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
07:31
Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
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Cited by 22 •
2019
Alcohol Use Disorder (AUD) is a major national health problem and the development of more effective treatments is required to offset the needs of this patient population. To this end, the following protocol utilizes two simple rodent drinking models to assess the preclinical efficacy of lead anti-alcohol compounds.
05:15
Intermittent Binge-Intake Model in Mice
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2025
A binge-eating model was established in mice using intermittent access to M&M's (a highly palatable food made of fat and sugar). Mice with intermittent access to this high-fat, high-sugar food showed stress-like behaviors, increased caloric intake, and a preference for that food over standard chow compared to mice with continuous or no access to the food.
07:28
Web-based Clinician Guide to Record Compatible Video of Standardized Drinking Task Kinematics for Computer Vision Analysis
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2025
Kinematic metrics of the drinking task have been recommended for use in upper limb stroke rehabilitation, but conventional approaches to kinematic studies are considered impractical. The current protocol describes a web-based guide to capture videos of the drinking task, which are compatible with computer vision to extract recommended kinematic metrics.
11:19
Preparation and Testing of Impedance-based Fluidic Biochips with RTgill-W1 Cells for Rapid Evaluation of Drinking Water Samples for Toxicity
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Cited by 12 •
2016
This manuscript describes how to prepare fluidic biochips with Rainbow trout gill epithelial cells for use in a field portable electric cell-substrate impedance sensor. The protocol for running a rapid drinking water toxicity test with the sensor is also described.
FAQs
Ethanol strengthens inhibitory signaling through GABA A receptors while reducing excitatory signaling through NMDA receptors. This combination shifts neural activity toward suppression, producing dose-dependent changes in judgment, coordination, memory, and consciousness. Pharmacology studies these receptor effects to connect ethanol exposure with observable behavioral and neurological outcomes.
The effects vary with the amount of ethanol reaching the brain because receptor-level inhibition and excitation are altered in a dose-dependent manner. Lower exposure may primarily affect judgment or coordination, whereas greater exposure can increasingly disrupt memory and consciousness. This progression helps researchers relate alcohol concentration to changing functional impairment.
Repeated episodes can modify neural reward and stress pathways rather than producing only temporary receptor effects. These adaptations may contribute to tolerance, in which alcohol’s effects change with repeated exposure, and to dependence, in which the nervous system becomes increasingly linked to alcohol. Such changes also help explain why withdrawal risk becomes an important pharmacological concern.
An isolated exposure is primarily examined for acute effects on judgment, coordination, memory, and consciousness. Repeated binge drinking adds a longer-term dimension because reward and stress pathways may be altered, contributing to tolerance, dependence, and withdrawal risk. Comparing these patterns allows pharmacologists to distinguish immediate ethanol actions from adaptations associated with recurring exposure.
Pharmacological investigations can examine ethanol’s acute effects, its influence on receptor signaling, and the resulting changes in behavior or consciousness. Studies may also assess how alcohol interacts with medications and how repeated exposure relates to tolerance, dependence, or withdrawal risk. These outcomes connect molecular mechanisms with clinically relevant patterns of alcohol use.
Alcohol can produce central nervous system effects through changes in inhibitory GABA A and excitatory NMDA signaling, so interactions with medications warrant focused study. Researchers evaluate whether medication exposure changes alcohol-related effects or whether combined pharmacological influences alter observed outcomes. This work supports safer interpretation of alcohol effects and informs prevention or treatment strategies.
Research findings can connect acute receptor actions with longer-term changes in reward and stress pathways. That connection helps investigators consider both immediate impairment and the development of tolerance, dependence, or withdrawal risk when evaluating prevention and treatment strategies. Pharmacological evidence therefore supports approaches addressing alcohol’s effects as well as the adaptations associated with repeated episodes.