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Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice
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Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice

Article DOI: 10.3791/2525-v • 07:56 min • May 5th, 2011
May 5th, 2011 •
1, 1, 1
1Department of Anesthesiology, University of Colorado

Kapitel

Summary
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A murine model for ventilator induced lung injury is an important tool to study an acute lung injury in vivo. Here, we report an easy applicable in situ model for acute lung injury using high-pressure mechanical ventilation to induce acute failure of the lung.

Tags

Pressure Controlled Ventilation Acute Lung Injury ALI Mice Murine Models Mechanical Ventilation Genetic Targets Pharmacological Targets Pulmonary Edema Pulmonary Gas Exchange Ventilator-induced Lung Injury C57BL/6 Mice Tracheotomy Inspiratory Peak Pressure Outcome Parameters Wet-to-dry Ratio Bronchoalveolar Fluid Albumin Content Myeloperoxidase Content Pulmonary Inflammation Treatment Groups Genotypes Gene-targeted Deletion
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