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Journal / Bioengineering / Transplantasjon av indusert pluripotent…
JoVE Journal
Bioengineering

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JoVE Journal Bioengineering
Transplantasjon av indusert pluripotent stamcelle-avledet Mesoangioblast-lignende myogene forfedre i musemodeller av muskelregenerering
Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
Journal (Bioengineering)
Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
Automated Slide Scanning and Segmentation in Fluorescently-labeled Tissues Using a Widefield High-content Analysis System
Journal (Bioengineering)
Automated Slide Scanning and Segmentation in Fluorescently-labeled Tissues Using a Widefield High-content Analysis System
 
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Transplantasjon av indusert pluripotent stamcelle-avledet Mesoangioblast-lignende myogene forfedre i musemodeller av muskelregenerering

Article DOI: 10.3791/50532-v • 10:03 min • January 20th, 2014
January 20th, 2014 •
*1, *1, 1, 1,2
1Department of Cell and Developmental Biology, University College London, 2Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Hospital
* These authors contributed equally

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Indusert pluripotent stamcelle (iPSC)-avledede myogene forfedre er lovende kandidater for celleterapi strategier for å behandle muskeldystrofier. Denne protokollen beskriver transplantasjon og funksjonelle målinger som kreves for å evaluere engraftment og differensiering av iPSC-avledede mesoangioblaster (en type muskelforfedere) i musemodeller av akutt og kronisk muskelregenerering.

Tags

Bioengineering Utgave 83 Skjelettmuskulatur Muskelceller Muskelfibre Skjelett Pericytter Stamceller Induserte Pluripotente stamceller (iPSCer) Muskeldystrofier Celledifferensiering dyremodeller muskelstamme/stamceller mesoangioblaster muskelregenerering iPSC-avledede mesoangioblaster (IDEM-er)
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