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Journal / Bioengineering / Chip de glomérulo renal isogênico projetado a…
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Bioengineering

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JoVE Journal Bioengineering
Chip de glomérulo renal isogênico projetado a partir de células-tronco pluripotentes induzidas por humanos
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Chip de glomérulo renal isogênico projetado a partir de células-tronco pluripotentes induzidas por humanos

Article DOI: 10.3791/63821-v • 10:23 min • November 4th, 2022
November 4th, 2022 •
1, 1,2,3,4
1Department of Biomedical Engineering, Pratt School of Engineering, Duke University, 2Department of Medicine, Division of Nephrology, Duke University School of Medicine, 3Department of Cell Biology, Duke University, 4Center for Biomolecular and Tissue Engineering, Duke University

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Apresentamos aqui um protocolo para projetar um sistema personalizado de organ-on-a-chip que recapitula a estrutura e a função da barreira de filtração glomerular renal, integrando células endoteliais epiteliais e vasculares geneticamente combinadas diferenciadas de células-tronco pluripotentes induzidas por humanos. Este sistema de bioengenharia pode avançar a medicina de precisão renal e aplicações relacionadas.

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Bioengenharia Edição 189
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