Biocompatibility Enhancement
Biocompatibility Enhancement - Related Videos
03:47
Implantation of a Flexible Biocompatible Probe in a Glioblastoma Mouse Model
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2025
Source: Lefevre, M. C., et al., Flexible Organic Electronic Devices for Pulsed Electric Field Therapy of Glioblastoma. J. Vis. Exp. (2022)This video demonstrates the implantation of a flexible, biocompatible probe in a glioblastoma mouse model to deliver targeted pulsed electric field therapy for neurotherapeutic applications.
13:38
Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures
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Cited by 9 •
2017
This study presents a methodology to prepare 3D, biodegradable, foam-like cell scaffolds based on biocompatible side-chain liquid crystal elastomers (LCEs). Confocal microscopy experiments show that foam-like LCEs allow for cell attachment, proliferation, and the spontaneous alignment of C2C12s myoblasts.
03:00
Self-Evaluation: Self-Enhancement and Self-Verification
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2020
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
08:09
Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
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Cited by 1 •
2019
This work presents the preparation of methionine functionalized biocompatible block copolymers (mBG) via the reversible addition-fragmentation chain transfer (RAFT) method. The plasmid DNA complexing ability of the obtained mBG and their transfection efficiency were also investigated. The RAFT method is very beneficial for polymerizing monomers containing special functional groups.
08:26
Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal Stenosis
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Cited by 13 •
2020
Laryngotracheal stenosis results from pathologic scar deposition that critically narrows the tracheal airway and lacks effective medical therapies. Using a PLLA-PCL (70% poly-L-lactide and 30% polycaprolactone) stent as a local drug delivery system, potential therapies aimed at decreasing scar proliferation in the trachea can be studied.
FAQs
Surface chemistry determines how biological fluids interact with a material and can therefore regulate which proteins adsorb at the interface. Because adsorbed proteins influence subsequent biological responses, controlling this first interaction may help reduce inflammatory or immune reactions and support more appropriate cell behavior. This mechanism is especially relevant when a device contacts tissue or biological fluids.
Surface roughness and wettability affect how cells and biological molecules interact with a material. Adjusting these properties can help create conditions that favor appropriate cell adhesion and growth rather than undesirable responses. In bioengineering, the selected surface characteristics should match the intended biological role, such as tissue integration for an implant or controlled cellular interaction with a scaffold.
Direct surface modification changes properties such as surface chemistry, roughness, or wettability, while a coating adds an additional layer intended to influence the biological interface. Both strategies can regulate protein adsorption and biological reactions, but their practical selection depends on which material properties need adjustment. Either approach may improve device interaction with cells, tissues, or fluids.
The main targets are protein adsorption, inflammatory reactions, immune responses, cell adhesion, and cell growth. These responses are interconnected: controlling the material interface can reduce unwanted biological activation while encouraging cellular behavior appropriate to the application. A successful design therefore considers both safety, such as limiting adverse reactions, and function, such as supporting tissue integration or scaffold performance.
A basic workflow begins by identifying the desired biological interaction, such as reduced immune reactivity or improved cell attachment. Engineers then select an appropriate surface modification, adjust roughness, wettability, or chemistry, or apply a coating. The resulting material is considered in relation to its intended use, because implants, biosensors, delivery systems, and scaffolds require different biological performance goals.
For medical implants, these strategies can support longer device function and better integration with surrounding tissue by aligning surface properties with biological responses. For tissue-engineering scaffolds, they can promote appropriate cell adhesion and growth. The same principle is applied differently in each case: implants emphasize safe, durable tissue contact, whereas scaffolds emphasize cellular interactions that support engineered tissue development.
In biosensors, modifying the interface can help control interactions with biological fluids and reduce unwanted biological responses that may interfere with device function. In drug-delivery systems, improved compatibility can support safer contact with tissues or fluids. These applications illustrate why surface chemistry, wettability, roughness, or coatings are selected according to the biological environment and intended device performance.