Microct Imaging
Microct Imaging - Related Videos
11:18
Micro-CT Imaging of a Mouse Spinal Cord
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2023
Source: Peiman Shahbeigi-Roodposhti and Sina Shahbazmohamadi, Biomedical Engineering Department, University of Connecticut, Storrs, Connecticut It's a little-known fact that the discovery and (inadvertent) use of X-rays garnered the first ever Nobel Prize in Physics. The famous X-ray image of Dr. Röntgen's wife's hand from 1895 that sent shock waves through the scientific community looks like most modern day 2D medical X-ray images. Though it is not the newest technology, X-ray absorption...
10:53
Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT
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Cited by 37 •
2012
A method of functional imaging of mouse brown adipose tissue (BAT) is described in which cold-stimulated uptake of 18F-Fluorodeoxyglucose (FDG) in BAT is non-invasively assessed with a standardized micro-PET/CT protocol. This method is robust and sensitive to detect differences in BAT activities in mouse models.
08:57
High Resolution 3D Imaging of Ex-Vivo Biological Samples by Micro CT
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Cited by 13 •
2011
Non-destructive volume visualization can be achieved only by tomographic techniques, of which the most efficient is the x-ray micro computerized tomography ( CT).
03:35
Contrast-Enhanced Micro-CT Imaging of Cerebral Cavernous Malformation Lesions in a Mouse Brain
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2025
Source: Choi, J. P. et al. Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model. J. Vis. Exp. (2017)This video demonstrates the use of micro-CT imaging to visualize cerebral cavernous malformation (CCM) lesions in a mouse brain. It details the steps for sample preparation, imaging, and 3D image reconstruction to evaluate the density and location of CCM lesions in brain tissue.
08:04
Monitoring Tumor Metastases and Osteolytic Lesions with Bioluminescence and Micro CT Imaging
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Cited by 22 •
2011
An experimental mouse model of bone metastasis was established following intracardiac delivery of luciferase expressing mammary tumor cells. Tumor development and resulted osteolytic lesion were monitored longitudinally with bioluminescence and micro CT imaging.
FAQs
As the specimen rotates, detectors capture projection images that record how internal regions attenuate the X-ray beam. Computational reconstruction combines these changing measurements into a volumetric map composed of voxels. Because the voxel values reflect attenuation differences, investigators can examine internal structure and derive measurements related to density, architecture, and defects within the scanned sample.
High spatial resolution allows investigators to examine fine features within trabecular and cortical bone, dental structures, vascular networks, and other small biological samples. This detail supports structural comparisons and defect assessment that may be difficult at lower resolution. The benefit must be considered alongside potentially substantial radiation exposure, which is one reason the technique is often used ex vivo.
The method is particularly informative for structures whose organization or defects are central to the research question. Medical studies commonly examine trabecular and cortical bone, dental structures, vascular networks, and small biological samples. These targets allow three-dimensional structural information to support investigations of bone disease, implant performance, tissue engineering, and treatment outcomes.
A typical workflow begins by positioning the specimen for rotation through an X-ray beam. Detectors collect projection images from multiple rotational positions, after which computational reconstruction converts the recorded attenuation differences into a three-dimensional voxel map. Investigators can then evaluate the resulting volume for structural features, density-related information, and defects relevant to the study.
The reconstructed volume supports quantitative assessment rather than visual inspection alone. Investigators can measure aspects of internal structure, density, and defects, using the voxel-based representation to compare samples or experimental conditions. In medical research, these outcomes help characterize bone and dental specimens, assess vascular networks, and examine changes associated with implants, tissue engineering, disease, or treatment.
This technique is useful when researchers need detailed three-dimensional evidence from small or structurally complex specimens. Its applications include studying bone disease, evaluating implant performance, examining tissue-engineering constructs, and assessing treatment outcomes. Because radiation exposure can be substantial and the method is frequently applied ex vivo, it is especially suited to controlled specimen-based investigations rather than routine examination of living patients.