Neurological Deficits

Neurological deficits are impairments in nervous system function that affect movement, sensation, coordination, language, cognition, or autonomic control, making them important indicators of injury or disease. They arise when damage or dysfunction in the brain, spinal cord, or peripheral nerves disrupts the transmission and processing of electrical signals between neural pathways and the body. In medicine, clinicians identify deficits through neurological examinations that assess strength, reflexes, sensation, balance, and mental status. Characterizing their pattern and progression helps localize lesions, distinguish conditions such as stroke, trauma, infection, and neurodegeneration, guide diagnostic testing and treatment, and monitor recovery or disease progression.

Neurological Deficits - Related Videos

Research

JoVE Journal - Neuroscience

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

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Cited by 21 •

2016

An optimized testing protocol is presented in this paper for the Rotarod performance test, used for measuring progressive neurological disability in TMEV-infected mice.

Research

JoVE Journal - Behavior
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Detecting Behavioral Deficits in Rats After Traumatic Brain Injury

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Cited by 56 •

2018

The goal of the behavioral tests presented here is to detect functional deficits in rats after traumatic brain injury. Four specific tests are presented that detect deficits in behaviors to reflect the damage to specific brain areas at times extending to one year after injury.

Generation of Induced Pluripotent Stem Cells from Turner Syndrome (45XO) Fetal Cells for Downstream Modelling of Neurological Deficits Associated with the Syndrome

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Cited by 3 •

2021

This protocol describes the generation of integration free iPSCs from fetal tissue fibroblasts through delivery of episomal plasmids by nucleofection followed by description of methods used for iPSC characterization and neuronal differentiation.

Lipidomics and Transcriptomics in Neurological Diseases

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Cited by 13 •

2022

This article presents a modular protocol for tissue lipidomics and transcriptomics, and plasma lipidomics in neurological disease mouse models targeting lipids underlying inflammation and neuronal activity, membrane lipids, downstream messengers, and mRNA-encoding enzymes/receptors underlying lipid function. Sampling, sample processing, extraction, and quantification procedures are outlined.

Reproducible Motor Deficit Following Aortic Occlusion in a Rat Model Of Spinal Cord Ischemia

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Cited by 4 •

2017

This study demonstrates the technique to make a minimally invasive and easily reproducible model of spinal cord ischemia in rats. Various degrees of hind limb motor deficit can be produced by controlling the aortic occlusion time.

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