Neurovascular Preservation

Neurovascular preservation is the protection of nerves and blood vessels from injury, dysfunction, or loss of blood flow during medical treatment, particularly surgery. It relies on detailed anatomical planning, careful tissue dissection, control of bleeding, and techniques that minimize traction, compression, thermal damage, and disruption of vascular supply; intraoperative imaging or neurophysiological monitoring may provide additional guidance. In medicine, preserving neurovascular structures helps maintain sensation, movement, organ perfusion, and wound healing while reducing complications. These principles are important in neurosurgery, orthopedics, vascular procedures, and cancer operations where disease or treatment may involve closely connected tissues.

Neurovascular Preservation - Related Videos

Research

JoVE EoE - Neuropathology

Generation of a Neurovascular Unit

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2025

Suspend the cell mixture in an extracellular matrix or ECM solution.

A Method for the Isolation of Neurovascular Units from Rat Brain

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2025

This video demonstrates the process of isolating brain microvessels from euthanized rats. It includes the dissection of the brain, cleaning of the tissue, and mechanical digestion, followed by repeated centrifugation to isolate the pure fraction of microvessels.

Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion

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2025

Donor heart preservation is a major determinant of success in heart transplantation. Technological advances have led to optimizing the conditions of preservation, along with a more accurate assessment of the donor heart before transplantation. We herein describe two innovative technologies currently applied for cardiac preservation: uniform cooling preservation and normothermic ex-situ heart perfusion.

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

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Cited by 14 •

2015

This protocol describes repetitive hypoxic preconditioning, or brief exposures to systemic hypoxia that reduce infarct volumes and blood-brain barrier disruption following transient middle cerebral artery occlusion in mice. It also details dual quantification of infarct volume and blood-brain barrier disruption after stroke to assess the efficacy of neurovascular protection.

The Analysis of Neurovascular Remodeling in Entorhino-hippocampal Organotypic Slice Cultures

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Cited by 11 •

2014

A protocol for entorhino-hippocampal organotypic slice cultures, which allows reproducing many aspects of ischemic brain injury, is presented. By studying changes of the neurovasculature in addition to changes in the neurons, this protocol is a versatile tool to study plastic changes in neural tissue after injury.

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