Skin Receptacle Interface

Skin Receptacle Interface refers to the functional boundary where external stimuli interact with sensory receptors in the skin and are conveyed to the nervous system. Mechanical pressure, vibration, temperature, or tissue deformation activate specialized receptors, which transduce these inputs into electrical signals carried by afferent neurons toward the spinal cord and brain. In neuroscience, this interface provides a framework for studying somatosensation and designing prosthetic limbs, wearable sensors, and haptic feedback systems that restore or augment touch. Its performance depends on stimulus encoding, receptor selectivity, signal timing, and compatibility with living tissue.

Skin Receptacle Interface - Related Videos

Research

JoVE Journal - Biology
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Generation of Human Induced Pluripotent Stem Cell-derived Planar Hair-bearing Skin Organoids Using an Air-Liquid Interface Culture System

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Cited by 1 •

2025

This protocol outlines a method for producing skin organoids containing hair follicles from human induced pluripotent stem cells using a planar, physiologically relevant air-liquid interface culture system to replicate skin architecture and function.

Research

JoVE EoE - Skin Cancer

Generation of Organotypic Full Skin Reconstructs: A Procedure to Establish 3D Skin Model Using Human Skin Samples

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2023

This video describes the detailed protocol for generating in vitro 3D organotypic skin reconstructs to study melanoma progression. This skin model mimics both the architecture and multicellular complexity of organs in vivo.

Education

JoVE Core - Molecular Biology

Protein-protein Interfaces

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2020

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

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Cited by 2 •

2025

Skin lesions are common and important features in many rheumatic diseases, and biopsy with pathological analysis plays a critical role in diagnosis. This article provides a detailed overview of the standardized skin biopsy procedure and, using discoid lupus erythematosus as an example, highlights the essential role of dermatopathology in diagnosing rheumatic diseases.

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

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Cited by 44 •

2015

Described herein is a protocol to isolate and analyze the infiltrating leukocytes of tissues at the maternal-fetal interface (uterus, decidua, and placenta) of mice. This protocol maintains the integrity of most cell surface markers and yields enough viable cells for downstream applications including flow cytometry analysis.

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