Pet Scans

PET scans, or positron emission tomography scans, are medical imaging methods that visualize physiological activity by tracking how tissues use a radiolabeled tracer. After the tracer emits positrons, these particles interact with electrons, producing pairs of gamma photons that detectors capture to reconstruct three-dimensional maps of processes such as glucose metabolism or neurotransmitter activity. In psychology and neuroscience, PET scans help researchers investigate brain function during cognition, emotion, and behavior, while also supporting the study of neurological and psychiatric conditions. Their ability to measure function rather than anatomy complements structural imaging and contributes to models of brain activity and mental processes.

Pet Scans - Related Videos

Research

JoVE EoE - Lung Cancer

FDG Based PET/CT Scan: A Method of Using Radiotracer for Non-invasive Imaging of Tumor Metabolism

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2023

This article describes multimodality imaging of cancerous tissues with PET and CT diagnostic imaging by using a radiotracer 18F-FDG. Cancerous tissue with high glycolytic activity uptakes more 18F-FDG.

Education

JoVE Core - Medical-Surgical Nursing

Radiological Investigation III: Pulmonary Angiogram and PET Scan

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2024

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan. Pulmonary Angiogram A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

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Cited by 4 •

2015

The method presented here uses simultaneous positron emission tomography and magnetic resonance imaging. In the cerebral hypoxia-ischemia model, dynamic changes in diffusion and glucose metabolism occur during and after injury. The evolving and irreproducible damage in this model necessitates simultaneous acquisition if meaningful multi-modal imaging data are to be acquired.

TSPO-PET/CT Imaging to Detect Infarct Formation in a Mouse Model of Ischemic Stroke

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2025

Source: Chaney, A. M., et.al. PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke. J. Vis. Exp. (2018). This video demonstrates a technique for in vivo imaging of neuroinflammation in a mouse model of ischemic stroke using a TSPO-specific radiotracer. Following injection, the radiotracer binds to TSPO, a protein located on the outer mitochondrial membrane and overexpressed in activated immune cells. A PET/CT scanner detects the radiotracer's distribution and...

Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT

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Cited by 37 •

2012

A method of functional imaging of mouse brown adipose tissue (BAT) is described in which cold-stimulated uptake of 18F-Fluorodeoxyglucose (FDG) in BAT is non-invasively assessed with a standardized micro-PET/CT protocol. This method is robust and sensitive to detect differences in BAT activities in mouse models.

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