A Neural Implant Design Toolbox for Nonhuman Primates

Rachel Iritani; Tiphaine Belloir; Devon J. Griggs; Zachary Ip; Zada Anderson; Azadeh Yazdan-Shahmorad

doi:10.3791/66167

Una caja de herramientas de diseño de implantes neurales para primates no humanos

JoVE Journal
Bioengineering

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JoVE Journal Bioengineering

A Neural Implant Design Toolbox for Nonhuman Primates

Una caja de herramientas de diseño de implantes neurales para primates no humanos

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06:33 min

February 9, 2024

DOI: 10.3791/66167-v

Rachel Iritani¹, Tiphaine Belloir¹, Devon J. Griggs², Zachary Ip¹, Zada Anderson³, Azadeh Yazdan-Shahmorad^1,2

¹Department of Bioengineering, Washington National Primate Research Center,University of Washington, ²Department of Electrical and Computer Engineering, Washington National Primate Research Center,University of Washington, ³Department of Biomedical Engineering,Purdue University

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Overview

This paper presents an automated method for neurosurgical planning in nonhuman primates using MRI scans. The approach allows for simultaneous extraction of brain and skull models, facilitating custom implant design.

Key Study Components

Area of Science

Neurosurgery
Medical Imaging
3D Modeling

Background

Neurosurgical planning for nonhuman primates is critical for various experiments.
Traditional methods often require multiple imaging processes.
Customized implants are essential to ensure animal welfare and experimental integrity.
Generic implants can lead to complications such as infection and instability.

Purpose of Study

To streamline the process of brain and skull modeling for surgical planning.
To reduce reliance on additional imaging techniques.
To enhance the design of custom implants for nonhuman primate experiments.

Methods Used

Automated extraction of brain and skull models from MRI scans.
Use of a single software platform for modeling.
Integration of 3D design software for implant creation.
Validation of models through 3D printing of anatomical replicas.

Main Results

Efficient modeling of brain and skull structures was achieved.
Elimination of the need for additional imaging processes.
Customized implants showed improved fit and reduced risk of complications.
The approach supports the welfare of nonhuman primates in research.

Conclusions

The automated method enhances neurosurgical planning efficiency.
Custom implants can significantly improve experimental outcomes.
This approach may set a new standard for NHP neurosurgery.

Frequently Asked Questions

What is the main advantage of this automated method?

It streamlines the modeling process and reduces the need for multiple imaging techniques.

How does this method impact animal welfare?

By providing better-fitting implants, it minimizes complications and enhances the wellbeing of the animals.

What imaging technique is primarily used in this study?

Magnetic resonance imaging (MRI) is the primary imaging technique utilized.

Can this method be applied to other species?

While this study focuses on nonhuman primates, the principles may be adaptable to other species.

What role does 3D printing play in this research?

3D printing is used to create life-size anatomical models for validation of the brain and skull models.

Is this method cost-effective?

Yes, by reducing the need for multiple imaging processes, it can lower overall costs in neurosurgical planning.

Este artículo describe los procesos automatizados para la planificación neuroquirúrgica de primates no humanos basados en imágenes de resonancia magnética (IRM). Estas técnicas utilizan pasos de procedimiento en plataformas de programación y diseño para respaldar el diseño de implantes personalizados para NHP. La validez de cada componente se puede confirmar utilizando modelos anatómicos tridimensionales (3D) impresos a tamaño real.

Nuestra investigación ofrece un método eficiente y automatizado para el modelado del cerebro y el cráneo, que es beneficioso para la planificación neuroquirúrgica y el diseño de implantes personalizados. Facilita la extracción simultánea de modelos de cerebro y cráneo utilizando una única plataforma de software, lo que elimina la necesidad de procesos de imagen adicionales, como tomografías conmutadas. En los últimos años, el modelado virtual del cerebro y el cráneo para imágenes médicas, como la resonancia magnética o la tomografía computarizada, se ha adoptado cada vez más para la planificación neuroquirúrgica de NHP.

Estos modelos, utilizados junto con el software de diseño 3D y la impresión 3D, permiten la creación de implantes personalizados adaptados a experimentos y animales específicos. Muchos experimentos de neurociencia con primates no humanos requieren el uso de cámaras craneales crónicas y postes en la cabeza. El uso de implantes genéricos introduce huecos entre el implante y el cráneo, lo que puede dar lugar a mayores tasas de infección, osteonecrosis e inestabilidad del implante, comprometiendo así los experimentos y el bienestar del animal.

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