Cecilia M. Giachelli

Publications

• Comparison of Osteoclast Differentiation Protocols from Human Induced Pluripotent Stem Cells of Different Tissue Origins
  Stem Cell Research & Therapy. Nov, 2023  |   Pubmed ID: 37936199
• Comparison of Osteoclast Differentiation Protocols from Human Induced Pluripotent Stem Cells of Different Tissue Origins
  Research Square. Jul, 2023  |   Pubmed ID: 37461708
• Dissecting Specific Wnt Components Governing Osteogenic Differentiation Potential by Human Periodontal Ligament Stem Cells Through Interleukin-6
  Scientific Reports. Jun, 2023  |   Pubmed ID: 37270571
• Role of Runx2 in Calcific Aortic Valve Disease in Mouse Models
  Frontiers in Cardiovascular Medicine. 2021  |   Pubmed ID: 34778386
• Engineered Osteoclasts Resorb Necrotic Alveolar Bone in Anti-RANKL Antibody-treated Mice
  Bone. Dec, 2021  |   Pubmed ID: 34375732
• Adapter Protein RapGEF1 Is Required for ERK1/2 Signaling in Response to Elevated Phosphate in Vascular Smooth Muscle Cells
  Journal of Vascular Research. 2021  |   Pubmed ID: 33951626
• Slc20a1/Pit1 and Slc20a2/Pit2 Are Essential for Normal Skeletal Myofiber Function and Survival
  Scientific Reports. Feb, 2020  |   Pubmed ID: 32080237
• PiT-2, a Type III Sodium-dependent Phosphate Transporter, Protects Against Vascular Calcification in Mice with Chronic Kidney Disease Fed a High-phosphate Diet
  Kidney International. Oct, 2018  |   Pubmed ID: 30041812
• Increased Calcific Aortic Valve Disease in Response to a Diabetogenic, Procalcific Diet in the LDLrApoB Mouse Model
  Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology. 2018  |   Pubmed ID: 29539583
• Role of Smooth Muscle Cells in Vascular Calcification: Implications in Atherosclerosis and Arterial Stiffness
  Cardiovascular Research. Mar, 2018  |   Pubmed ID: 29514202
• Loss of PiT-2 Results in Abnormal Bone Development and Decreased Bone Mineral Density and Length in Mice
  Biochemical and Biophysical Research Communications. Jan, 2018  |   Pubmed ID: 29133259
• Noncanonical Wnts at the Cusp of Fibrocalcific Signaling Processes in Human Calcific Aortic Valve Disease
  Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2017  |   Pubmed ID: 28228443
• Osteoclast Precursors Do Not Express CD68: Results from CD68 Promoter-driven RANK Transgenic Mice
  FEBS Letters. Mar, 2017  |   Pubmed ID: 28173622
• Vascular Calcification in CKD-MBD: Roles for Phosphate, FGF23, and Klotho
  Bone. Jul, 2017  |   Pubmed ID: 27847254
• SLC20A2 Deficiency in Mice Leads to Elevated Phosphate Levels in Cerbrospinal Fluid and Glymphatic Pathway-Associated Arteriolar Calcification, and Recapitulates Human Idiopathic Basal Ganglia Calcification
  Brain Pathology (Zurich, Switzerland). 01, 2017  |   Pubmed ID: 26822507
• Runx2 Deletion in Smooth Muscle Cells Inhibits Vascular Osteochondrogenesis and Calcification but Not Atherosclerotic Lesion Formation
  Cardiovascular Research. Nov, 2016  |   Pubmed ID: 27671804
• Osteopontin Protects Against High Phosphate-induced Nephrocalcinosis and Vascular Calcification
  Kidney International. May, 2016  |   Pubmed ID: 27083280
• Slc20a2 Deficiency Results in Fetal Growth Restriction and Placental Calcification Associated with Thickened Basement Membranes and Novel CD13 and Lamininα1 Expressing Cells
  Reproductive Biology. Mar, 2016  |   Pubmed ID: 26952749
• Runx2 Expression in Smooth Muscle Cells Is Required for Arterial Medial Calcification in Mice
  The American Journal of Pathology. Jul, 2015  |   Pubmed ID: 25987250
• Phosphate Uptake-independent Signaling Functions of the Type III Sodium-dependent Phosphate Transporter, PiT-1, in Vascular Smooth Muscle Cells
  Experimental Cell Research. Apr, 2015  |   Pubmed ID: 25684711
• Calcific Aortic Valve Disease: a Consensus Summary from the Alliance of Investigators on Calcific Aortic Valve Disease
  Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2014  |   Pubmed ID: 25189570
• A Current Understanding of Vascular Calcification in CKD
  American Journal of Physiology. Renal Physiology. Oct, 2014  |   Pubmed ID: 25143458
• Loss of PiT-1 Results in Abnormal Endocytosis in the Yolk Sac Visceral Endoderm
  Mechanisms of Development. Aug, 2014  |   Pubmed ID: 25138534
• Engineered Biomaterials Control Differentiation and Proliferation of Human-embryonic-stem-cell-derived Cardiomyocytes Via Timed Notch Activation
  Stem Cell Reports. Mar, 2014  |   Pubmed ID: 24672751
• An Inducible, Ligand-independent Receptor Activator of NF-κB Gene to Control Osteoclast Differentiation from Monocytic Precursors
  PloS One. 2013  |   Pubmed ID: 24386387
• Sodium-dependent Phosphate Cotransporters and Phosphate-induced Calcification of Vascular Smooth Muscle Cells: Redundant Roles for PiT-1 and PiT-2
  Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2013  |   Pubmed ID: 23968976
• Vascular Calcification: an Update on Mechanisms and Challenges in Treatment
  Calcified Tissue International. Oct, 2013  |   Pubmed ID: 23456027
• Fibroblast Growth Factor 23 is Not Associated with and Does Not Induce Arterial Calcification
  Kidney International. Jun, 2013  |   Pubmed ID: 23389416
• Prevascularized Microtemplated Fibrin Scaffolds for Cardiac Tissue Engineering Applications
  Tissue Engineering. Part A. Apr, 2013  |   Pubmed ID: 23317311
• Osteopontin Mediates Macrophage Chemotaxis Via α4 and α9 Integrins and Survival Via the α4 Integrin
  Journal of Cellular Biochemistry. May, 2013  |   Pubmed ID: 23192608
• Smooth Muscle Cell Plasticity: Fact or Fiction?
  Circulation Research. Jan, 2013  |   Pubmed ID: 23093573
• High Phosphate Feeding Promotes Mineral and Bone Abnormalities in Mice with Chronic Kidney Disease
  Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Jan, 2013  |   Pubmed ID: 23045434
• RANKL Enhances Macrophage Paracrine Pro-calcific Activity in High Phosphate-treated Smooth Muscle Cells: Dependence on IL-6 and TNF-α
  Journal of Vascular Research. 2012  |   Pubmed ID: 22948607
• Vitamin D Receptor Agonists Increase Klotho and Osteopontin While Decreasing Aortic Calcification in Mice with Chronic Kidney Disease Fed a High Phosphate Diet
  Kidney International. Dec, 2012  |   Pubmed ID: 22932118
• Engineering Biomaterials to Integrate and Heal: the Biocompatibility Paradigm Shifts
  Biotechnology and Bioengineering. Aug, 2012  |   Pubmed ID: 22592568
• Sources of Cells That Contribute to Atherosclerotic Intimal Calcification: an in Vivo Genetic Fate Mapping Study
  Cardiovascular Research. Jun, 2012  |   Pubmed ID: 22436847
• Combination of Sleeping Beauty Transposition and Chemically Induced Dimerization Selection for Robust Production of Engineered Cells
  Nucleic Acids Research. Jun, 2012  |   Pubmed ID: 22402491
• Arterial Calcification in Chronic Kidney Disease: Key Roles for Calcium and Phosphate
  Circulation Research. Sep, 2011  |   Pubmed ID: 21885837
• Direct Effects of Phosphate on Vascular Cell Function
  Advances in Chronic Kidney Disease. Mar, 2011  |   Pubmed ID: 21406295
• Elastin Degradation and Vascular Smooth Muscle Cell Phenotype Change Precede Cell Loss and Arterial Medial Calcification in a Uremic Mouse Model of Chronic Kidney Disease
  The American Journal of Pathology. Feb, 2011  |   Pubmed ID: 21281809
• Matrix Remodeling in Vascular Calcification Associated with Chronic Kidney Disease
  Journal of the American Society of Nephrology : JASN. Oct, 2010  |   Pubmed ID: 20798261
• Phosphate and Vascular Calcification: Emerging Role of the Sodium-dependent Phosphate Co-transporter PiT-1
  Thrombosis and Haemostasis. Sep, 2010  |   Pubmed ID: 20664908
• Runx2/Cbfa1, but Not Loss of Myocardin, is Required for Smooth Muscle Cell Lineage Reprogramming Toward Osteochondrogenesis
  Journal of Cellular Biochemistry. Jul, 2010  |   Pubmed ID: 20564193
• Characterization of Mandibular Bone in a Mouse Model of Chronic Kidney Disease
  Journal of Periodontology. Feb, 2010  |   Pubmed ID: 20151810
• Vitamin D Receptor Activators Induce an Anticalcific Paracrine Program in Macrophages: Requirement of Osteopontin
  Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2010  |   Pubmed ID: 19948844
• Discoidin Domain Receptor-1 Deficiency Attenuates Atherosclerotic Calcification and Smooth Muscle Cell-mediated Mineralization
  The American Journal of Pathology. Dec, 2009  |   Pubmed ID: 19893047
• Generation of Mouse Conditional and Null Alleles of the Type III Sodium-dependent Phosphate Cotransporter PiT-1
  Genesis (New York, N.Y. : 2000). Dec, 2009  |   Pubmed ID: 19882669
• The Role of Osteopontin in Inflammatory Processes
  Journal of Cell Communication and Signaling. Dec, 2009  |   Pubmed ID: 19798593
• Immobilization of Alkaline Phosphatase on Microporous Nanofibrous Fibrin Scaffolds for Bone Tissue Engineering
  Biomaterials. Sep, 2009  |   Pubmed ID: 19501906
• Phosphate Feeding Induces Arterial Medial Calcification in Uremic Mice: Role of Serum Phosphorus, Fibroblast Growth Factor-23, and Osteopontin
  Kidney International. Jun, 2009  |   Pubmed ID: 19322138
• Smooth Muscle Cells Give Rise to Osteochondrogenic Precursors and Chondrocytes in Calcifying Arteries
  Circulation Research. Mar, 2009  |   Pubmed ID: 19197075
• The Emerging Role of Phosphate in Vascular Calcification
  Kidney International. May, 2009  |   Pubmed ID: 19145240
• Osteoprotegerin and RANKL Differentially Regulate Angiogenesis and Endothelial Cell Function
  Angiogenesis. 2009  |   Pubmed ID: 19105036
• Methods to Promote Notch Signaling at the Biomaterial Interface and Evaluation in a Rafted Organ Culture Model
  Journal of Biomedical Materials Research. Part A. Nov, 2009  |   Pubmed ID: 18985776
• Role of Carbonic Anhydrase II in Ectopic Calcification
  Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology. 2009  |   Pubmed ID: 18402839
• Microporous Nanofibrous Fibrin-based Scaffolds for Bone Tissue Engineering
  Biomaterials. Oct, 2008  |   Pubmed ID: 18640716
• Crosslinking of an Oesophagus Acellular Matrix Tissue Scaffold
  Journal of Tissue Engineering and Regenerative Medicine. Aug, 2008  |   Pubmed ID: 18618611
• The Influence of Surface Mineral and Osteopontin on the Formation and Function of Murine Bone Marrow-derived Osteoclasts
  Journal of Materials Science. Materials in Medicine. Oct, 2008  |   Pubmed ID: 18483788
• BMP-2 Promotes Phosphate Uptake, Phenotypic Modulation, and Calcification of Human Vascular Smooth Muscle Cells
  Atherosclerosis. Aug, 2008  |   Pubmed ID: 18179800
• A Fibrinogen-based Precision Microporous Scaffold for Tissue Engineering
  Biomaterials. Dec, 2007  |   Pubmed ID: 17765302
• Osteopontin: a Multifunctional Molecule Regulating Chronic Inflammation and Vascular Disease
  Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2007  |   Pubmed ID: 17717292
• Delivery of Non-viral Gene Carriers from Sphere-templated Fibrin Scaffolds for Sustained Transgene Expression
  Biomaterials. Nov, 2007  |   Pubmed ID: 17675152
• Sodium-dependent Phosphate Cotransporters and Vascular Calcification
  Current Opinion in Nephrology and Hypertension. Jul, 2007  |   Pubmed ID: 17565274
• Mechanisms of Vascular Calcification
  Advances in Chronic Kidney Disease. Jan, 2007  |   Pubmed ID: 17200044
• Molecular Mediators of Alphavbeta3-induced Endothelial Cell Survival
  Journal of Vascular Research. 2006  |   Pubmed ID: 16888388
• Osteoprotegerin Inactivation Accelerates Advanced Atherosclerotic Lesion Progression and Calcification in Older ApoE-/- Mice
  Arteriosclerosis, Thrombosis, and Vascular Biology. Sep, 2006  |   Pubmed ID: 16840715
• Mimicking Cell-cell Interactions at the Biomaterial-cell Interface for Control of Stem Cell Differentiation
  Journal of Biomedical Materials Research. Part A. Oct, 2006  |   Pubmed ID: 16758464
• Development of an Esophagus Acellular Matrix Tissue Scaffold
  Tissue Engineering. Feb, 2006  |   Pubmed ID: 16548690
• Role of the Sodium-dependent Phosphate Cotransporter, Pit-1, in Vascular Smooth Muscle Cell Calcification
  Circulation Research. Apr, 2006  |   Pubmed ID: 16527991
• Arteriosclerosis, Calcium Phosphate Deposition and Cardiovascular Disease in Uremia: Current Concepts at the Bench
  Current Opinion in Nephrology and Hypertension. Nov, 2005  |   Pubmed ID: 16205469
• Activation of IKKbeta by Glucose is Necessary and Sufficient to Impair Insulin Signaling and Nitric Oxide Production in Endothelial Cells
  Journal of Molecular and Cellular Cardiology. Aug, 2005  |   Pubmed ID: 15978611
• The Role of Osteopontin in Foreign Body Giant Cell Formation
  Biomaterials. Oct, 2005  |   Pubmed ID: 15949549
• Controlling Osteopontin Orientation on Surfaces to Modulate Endothelial Cell Adhesion
  Journal of Biomedical Materials Research. Part A. Jul, 2005  |   Pubmed ID: 15920735
• Esophageal Epithelial Cell Interaction with Synthetic and Natural Scaffolds for Tissue Engineering
  Biomaterials. Nov, 2005  |   Pubmed ID: 15913763
• Calcification of Advanced Atherosclerotic Lesions in the Innominate Arteries of ApoE-deficient Mice: Potential Role of Chondrocyte-like Cells
  Arteriosclerosis, Thrombosis, and Vascular Biology. Jul, 2005  |   Pubmed ID: 15845913
• Regulation of Vascular Calcification: Roles of Phosphate and Osteopontin
  Circulation Research. Apr, 2005  |   Pubmed ID: 15831823
• Smooth Muscle Cells Deficient in Osteopontin Have Enhanced Susceptibility to Calcification in Vitro
  Cardiovascular Research. May, 2005  |   Pubmed ID: 15820201
• Mitigation of Ectopic Calcification in Osteopontin-deficient Mice by Exogenous Osteopontin
  Calcified Tissue International. Apr, 2005  |   Pubmed ID: 15812576
• Free Fatty Acid Impairment of Nitric Oxide Production in Endothelial Cells is Mediated by IKKbeta
  Arteriosclerosis, Thrombosis, and Vascular Biology. May, 2005  |   Pubmed ID: 15731493
• Src Kinase Activity is Required for Integrin AlphaVbeta3-mediated Activation of Nuclear Factor-kappaB
  The Journal of Biological Chemistry. Apr, 2005  |   Pubmed ID: 15695822
• Vascular Calcification Mechanisms
  Journal of the American Society of Nephrology : JASN. Dec, 2004  |   Pubmed ID: 15579497
• The CC Chemokine Ligand, CCL2/MCP1, Participates in Macrophage Fusion and Foreign Body Giant Cell Formation
  The American Journal of Pathology. Dec, 2004  |   Pubmed ID: 15579457
• Elevated Extracellular Calcium Levels Induce Smooth Muscle Cell Matrix Mineralization in Vitro
  Kidney International. Dec, 2004  |   Pubmed ID: 15569318
• Mechanisms of Vascular Calcification in Uremia
  Seminars in Nephrology. Sep, 2004  |   Pubmed ID: 15490398
• Hyaluronic Acid Grafting Mitigates Calcification of Glutaraldehyde-fixed Bovine Pericardium
  Journal of Biomedical Materials Research. Part A. Aug, 2004  |   Pubmed ID: 15227678
• Enhancing the Biological Activity of Immobilized Osteopontin Using a Type-1 Collagen Affinity Coating
  Journal of Biomedical Materials Research. Part A. Jul, 2004  |   Pubmed ID: 15174104
• Regulation of Cardiovascular Calcification
  Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology. 2004  |   Pubmed ID: 15033154
• Adhesive Protein Interactions with Chitosan: Consequences for Valve Endothelial Cell Growth on Tissue-engineering Materials
  Journal of Biomedical Materials Research. Part A. Nov, 2003  |   Pubmed ID: 14566796
• Expression and Function of the Integrin Alpha9beta1 in Bovine Aortic Valve Interstitial Cells
  The Journal of Heart Valve Disease. Sep, 2003  |   Pubmed ID: 14565714
• Characterization and Analysis of Osteopontin-immobilized Poly(2-hydroxyethyl Methacrylate) Surfaces
  Journal of Biomedical Materials Research. Part A. Oct, 2003  |   Pubmed ID: 14517893
• Biomimetic Peptides That Engage Specific Integrin-dependent Signaling Pathways and Bind to Calcium Phosphate Surfaces
  Journal of Biomedical Materials Research. Part A. Oct, 2003  |   Pubmed ID: 14517863
• Vascular Calcification: in Vitro Evidence for the Role of Inorganic Phosphate
  Journal of the American Society of Nephrology : JASN. Sep, 2003  |   Pubmed ID: 12939385
• Immunohistologic Labeling of Murine Endothelium
  Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology. Mar-Apr, 2003  |   Pubmed ID: 12684163
• Osteopontin Inhibits Mineral Deposition and Promotes Regression of Ectopic Calcification
  The American Journal of Pathology. Dec, 2002  |   Pubmed ID: 12466120
• Inactivation of the Osteopontin Gene Enhances Vascular Calcification of Matrix Gla Protein-deficient Mice: Evidence for Osteopontin As an Inducible Inhibitor of Vascular Calcification in Vivo
  The Journal of Experimental Medicine. Oct, 2002  |   Pubmed ID: 12391016
• Effects of Cyclosporine in Osteopontin Null Mice
  Kidney International. Jul, 2002  |   Pubmed ID: 12081566
• Ectopic Calcification: Gathering Hard Facts About Soft Tissue Mineralization
  The American Journal of Pathology. Mar, 1999  |   Pubmed ID: 10079244
• NF-kappaB Mediates Alphavbeta3 Integrin-induced Endothelial Cell Survival
  The Journal of Cell Biology. May, 1998  |   Pubmed ID: 9585425