Douglas S. Auld Chemical Biology and Therapeutics Novartis Institutes for Biomedical Research Biography Publications Institution JoVE Articles Douglas S. Auld has not added a biography. If you are Douglas S. Auld and would like to personalize this page please email our Author Liaison for assistance. Publications Characterization and Use of TurboLuc Luciferase As a Reporter for High-Throughput Assays Biochemistry. Aug, 2018 | Pubmed ID: 29641191 Bioluminescence Methods for Assaying Kinases in Quantitative High-Throughput Screening (qHTS) Format Applied to Yes1 Tyrosine Kinase, Glucokinase, and PI5P4Kα Lipid Kinase Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26501901 Variomics Screen Identifies the Re-entrant Loop of the Calcium-activated Chloride Channel ANO1 That Facilitates Channel Activation The Journal of Biological Chemistry. Jan, 2015 | Pubmed ID: 25425649 Composition and Applications of Focus Libraries to Phenotypic Assays Frontiers in Pharmacology. 2014 | Pubmed ID: 25104937 Biochemical, Cellular, and Biophysical Characterization of a Potent Inhibitor of Mutant Isocitrate Dehydrogenase IDH1 The Journal of Biological Chemistry. May, 2014 | Pubmed ID: 24668804 Application of Titration-Based Screening for the Rapid Pilot Testing of High-Throughput Assays Journal of Biomolecular Screening. Jun, 2014 | Pubmed ID: 24246376 Bioluminescent Assays for Cytochrome P450 Enzymes Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23475663 A Homogeneous, High-throughput Assay for Phosphatidylinositol 5-phosphate 4-kinase with a Novel, Rapid Substrate Preparation PloS One. 2013 | Pubmed ID: 23326584 Comparison of Compound Administration Methods in Biochemical Assays: Effects on Apparent Compound Potency Using Either Assay-ready Compound Plates or Pin Tool-delivered Compounds Journal of Biomolecular Screening. Jan, 2013 | Pubmed ID: 22904199 Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening Lesley Mathews Griner1, Kalyani Gampa1, Toan Do2, Huyen Nguyen2, David Farley2, Christopher J. Hogan2, Douglas S. Auld2, Serena J. Silver1 1Oncology Drug Discovery: Molecular Pharmacology, Novartis Institutes for Biomedical Research, 2Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research JoVE 57476 Recherche en cancérologie
Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening Lesley Mathews Griner1, Kalyani Gampa1, Toan Do2, Huyen Nguyen2, David Farley2, Christopher J. Hogan2, Douglas S. Auld2, Serena J. Silver1 1Oncology Drug Discovery: Molecular Pharmacology, Novartis Institutes for Biomedical Research, 2Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research JoVE 57476 Recherche en cancérologie