Orthotopic Graft Placement
Orthotopic Graft Placement - Related Videos
04:43
Orthotopic Porcine Kidney Transplantation: A Technique to Transplant Graft Kidney in Porcine Model
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This video describes orthotopic kidney auto-transplantation in a porcine model. This surgical procedure involves the transplantation of an animal's kidney graft at its original anatomical location. The model is used to investigate new treatments for end-stage kidney diseases in humans.
09:16
Orthotopic Small Bowel Transplantation in Rats
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Small bowel transplantation has become an accepted treatment option for patients with irreversible intestinal failure. Our experimental model of orthotopic small bowel transplantation in rats serves as a reliable tool to address underlying immunologic and inflammatory processes that complicate intestinal transplantation.
06:57
Arterial Line Placement
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2023
Source: Sharon Bord, MD, Department of Emergency Medicine, The Johns Hopkins University School of Medicine, Maryland, USA When monitoring patients, it is important to obtain values that are accurate and reliable. Blood pressure monitoring is one of the essential vital signs, and for a majority of patients, measuring it utilizing non-invasive techniques provides accurate values. However, there are situations in which the blood pressure requires more exact, specific, and reliable measurements.
07:15
Orthotopic Hind Limb Transplantation in the Mouse
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Cited by 24 •
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This novel model for orthotopic hind limb transplantation in the mouse, applying a non-suture cuff technique for super-microvascular anastomosis, provides a powerful tool for in vivo mechanistic immunological research related to vascularized composite allotransplantation (VCA).
08:43
Orthotopic Mouse Model of Colorectal Cancer
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Cited by 109 •
2007
Two techniques can be used to establish this model: injection of a cancer cell suspension into the cecal wall or transplantation of a piece of subcutaneous tumor onto the cecum. This model is useful for studying the natural progression of colorectal cancer and testing new therapeutic agents against colorectal cancer.
FAQs
Immune recognition determines whether recipient defenses tolerate or attack the transplanted material. In an orthotopic model, immune cells encounter donor antigens within the relevant tissue environment, allowing investigators to examine rejection alongside local inflammatory responses. This makes graft survival a measurable outcome of host compatibility and immune activation.
Vascular integration connects graft and recipient tissues, while the surrounding microenvironment supplies the local context for graft function and immune behavior. These interactions influence whether the transplanted material becomes established. Studying them at the relevant anatomical site helps investigators relate graft establishment to local structure, function, and tissue-specific conditions.
Compatibility affects how recipient and donor elements interact, whereas inflammation can disrupt establishment even when anatomical placement is appropriate. Infection control adds another constraint because pathogens and host defenses may alter the graft environment. Considering these factors together helps researchers interpret poor graft survival without attributing every outcome solely to immune rejection.
A study plan should specify donor material and recipient context, then prioritize placement that preserves relevant local structure and function. Investigators should evaluate compatibility, vascular integration, inflammation, infection control, and graft establishment. These considerations align the model with its intended question, whether survival, immune response, or disease progression.
Because the graft remains within a physiologically relevant tissue setting, the model can support examination of how pathogens behave in relation to local structures, graft tissue, and host defenses. Investigators can connect pathogen behavior with inflammation, immune responses, and disease progression, rather than treating infection as an isolated event.
These models can be used to evaluate immunosuppressive strategies, vaccines, and antimicrobial interventions in the setting of graft survival and disease progression. Their value lies in linking treatment effects to immune responses, infection control, and the graft microenvironment. Results can therefore inform how an intervention influences both the transplanted material and host defenses.