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Immunology and Infection

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Vurdering af Innate Sensing af HIV-1 inficerede CD4
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Vurdering af Innate Sensing af HIV-1 inficerede CD4

Article DOI: 10.3791/51207-v • 08:11 min • September 1st, 2015
September 1st, 2015 •
1, 1, 1,2
1Laboratory of Human Retrovirology, Institut de Recherches Cliniques de Montréal (IRCM), 2Department of Microbiology, Infectiology, and Immunology, Université de Montréal

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I modsætning cellefrie HIV-1-partikler, er inficeret CD4 + T-celler effektivt registreres af plasmacytoide dendritiske celler (pdCs). Dette håndskrift beskriver en fremgangsmåde, hvor perifere mononukleære blodceller (PBMC'er) eller isolerede pdCs dyrkes sammen med HIV-1-inficerede T-celler til at evaluere medfødte sensing af pdCs som vurderet ved frigivelse af type I-IFN.

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Immunologi HIV-infektioner Immunity Innate HIV-1 PDC medfødte sensing Type-I IFN
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