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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Article DOI: 10.3791/51471-v • 11:04 min • September 1st, 2014
September 1st, 2014 •
2,5, 2,5, 1,5, 3,5, 1,5, 4,5
1Department of Biomedical Engineering, Washington University in St. Louis, 2Department of Physics, Washington University in St. Louis, 3Division of Biology and Biomedical Sciences, Washington University in St. Louis, 4Department of Medicine, Cardiovascular Division, Washington University in St. Louis, 5Cardiovascular Biophysics Lab, Washington University in St. Louis

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Accurate, causality-based quantification of global diastolic function has been achieved by kinematic modeling-based analysis of transmitral flow via the Parametrized Diastolic Filling (PDF) formalism. PDF generates unique stiffness, relaxation, and load parameters and elucidates 'new' physiology while providing sensitive and specific indexes of dysfunction.

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Quantification Global Diastolic Function Kinematic Modeling Transmitral Flow Parametrized Diastolic Filling Formalism Cardiac Function Assessment Invasive Methods Noninvasive Imaging Modalities Echocardiography MRI CT Chamber Dimension Blood/tissue Motion Physiologic Causal Determinants Left Ventricles Mechanical Suction Pumps Laws Of Motion Equation Of Motion Parametrized Diastolic Filling (PDF) Formalism Early Transmitral Flow Patterns Damped Oscillatory Motion
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