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Ex Vivo Treatment Response av primære svulster og / eller Associated metastaser for preklinisk og klinisk utvikling av legemiddel

Article DOI: 10.3791/52157-v • 08:29 min • October 2nd, 2014
October 2nd, 2014 •
*1, *2, 3, 4, 5, 5, 2, 6
1Department of Pathology, Memorial Sloan Kettering Cancer Center, 2Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, 3Department of Radiology, Weill Cornell Medical College, 4Department of Medicine, Memorial Sloan Kettering Cancer Center, 5Department of Oncology, Memorial Sloan Kettering Cancer Center, 6Department of Surgery, Memorial Sloan Kettering Cancer Center
* These authors contributed equally

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Etablerte kreftcellelinjer og xenografts har vært bærebjelken i kreftforskningen de siste tiårene. Imidlertid tyder nyere bevis på at terapeutisk respons er sterkt påvirket av svulsten celle mikromiljøet. Derfor har vi utviklet en ex vivo analyse av primære vevsprøver for narkotikautviklingsformål.

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Cancer Biology , behandlingsrespons følsomhet / resistens narkotika utvikling Pasient svulster preklinisk og klinisk
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