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Ved hjelp av RNA-sekvensering for å oppdage Novel Splice Varianter Relatert til Drug Resistance in

Article DOI: 10.3791/54714-v • 09:58 min • December 9th, 2016
December 9th, 2016 •
1,2,3, 1, 4, 3, 5, 6, 1,7, *1, *3,8,9
1Department of Pediatric Oncology/Hematology, VU University Medical Center, 2Department of Hematology, VU University Medical Center, 3Department of Medical Oncology, VU University Medical Center, 4Department of Clinical Genetics, VU University Medical Center, 5Division of General and Transplant Surgery, Azienda Ospedaliera Universitaria Pisana, Universita’ di Pisa, 6Amsterdam Immunology and Rheumatology Center, VU University Medical Center, 7Princess Máxima Center for Pediatric Oncology, 8Cancer Pharmacology Lab, AIRC Start-Up Unit, University of Pisa, 9Institute of Nanoscience and Nanotechnology, CNR-Nano
* These authors contributed equally

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Her beskriver vi en protokoll for å undersøke virkningen av avvikende spleising på legemiddelresistens i solide svulster og hematologisk malignitet. Til dette målet, analyserte vi transcriptomic profiler av foreldre og resistente in vitro modeller gjennom RNA-seq og etablert en QRT-PCR basert metode for å validere kandidat gener.

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Cancer Research kjemoterapi motstand cytotoksisitet alternativ spleising RNA-seq transcriptomics
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