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JoVE Journal Chemistry
Hedeflenen Plasmid DNA teslim için metiyonin functionalized biyouyumlu blok kopolimerler
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Hedeflenen Plasmid DNA teslim için metiyonin functionalized biyouyumlu blok kopolimerler

Article DOI: 10.3791/58527-v • 08:09 min • August 6th, 2019
August 6th, 2019 •
*1, *2, 2, 3, 2, 3, 1, 2
1Research Center of Clinical Oncology, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Nanjing Medical University Affiliated Cancer Hospital, 2Department of General Surgery, The First Affiliated Hospital with Nanjing Medical University, 3School of Clinical Medicine, Xuzhou Medical University
* These authors contributed equally

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Bu çalışma, geri dönüşümlü ek-parçalanma zinciri transferi (RAFT) yöntemi ile metiyonin functionalized biyouyumlu blok kopolimerler (mBG) hazırlanması sunar. Elde edilen mBG 'nin plazmid DNA 'Sı karmaşıklığı ve transfeksiyon verimliliği de incelenmiştir. Raft yöntemi, özel fonksiyonel gruplar içeren polimerleştirici monomerlerin için çok yararlıdır.

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Kimya sayı 150 geri dönüşümlü ek-parçalanma zinciri transferi RAFT ilaç teslim sistemi DDS metiyonin guanidine n-(3-aminoprotransl) methacrylamid hidroklorür apma n,n-bis(2-hidroksietil) metakrilamid BNHEMA
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