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Immunology and Infection

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JoVE Journal Immunology and Infection
En TNBS-indusert gnagermodell for å studere den patogene rollen som mekanisk stress i Crohns sykdom
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En TNBS-indusert gnagermodell for å studere den patogene rollen som mekanisk stress i Crohns sykdom

Article DOI: 10.3791/63499-v • 05:08 min • March 1st, 2022
March 1st, 2022 •
*1, *1, *1, 2, 1
1Department of Internal Medicine, the University of Texas Medical Branch, 2Department of Pathology, the University of Texas Medical Branch
* These authors contributed equally

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Den nåværende protokollen beskriver utviklingen av en Crohns-lignende kolittmodell hos gnagere. Transmural betennelse fører til stenose på TNBS innåndingssted, og mekanisk utvidelse observeres i segmentet proksimalt til stenose. Disse endringene tillater å studere mekanisk stress i kolitt.

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Immunologi og infeksjon utgave 181
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