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JoVE Journal Bioengineering
Subretinal implantasjon av RPE på en bærer i minigriser
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Subretinal implantasjon av RPE på en bærer i minigriser: retningslinjer for preoperative preparater, kirurgiske teknikker og postoperativ behandling

Article DOI: 10.3791/63505-v • 11:06 min • November 11th, 2022
November 11th, 2022 •
*1,2, *3, 4, 4, 4, 5,6, 5,6, 5,6, 5,6, 5,6, 5, 5, 5, 5, 7, 8, 9, 10, 11, 1, 1, 5, *8, *5
1Eye Clinic, Department of Ophthalmology, University Hospital Giessen and Marburg GmbH, 2Karl Landsteiner Institute for Retinal Research and Imaging, 3Department of Ophthalmology, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University in Prague, 4Institute of Macromolecular Chemistry, Czech Academy of Sciences, 5Institute of Animal Physiology and Genetics, Czech Academy of Sciences, 6Department of Cell Biology, Faculty of Science, Charles University, 7Institute of Experimental Medicine, Czech Academy of Sciences, 8Center for Eye Research, Department of Ophthalmology, Oslo University Hospital and Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 9Moorfields Eye Hospitals UAE, 10Stem Cell Therapies in Neurodegenerative Diseases Lab, Research Center “Principe Felipe”, 11Eye Center Donaustadt, Department of Ophthalmology, Sigmund Freud University
* These authors contributed equally

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Den subretinale implantasjonen av retinalpigmentert epitel (RPE) er en av de mest lovende tilnærmingene for behandling av degenerative retinale sykdommer. Imidlertid er ytelsen til prekliniske studier på store øyedyrmodeller fortsatt utfordrende. Denne rapporten presenterer retningslinjer for subretinal transplantasjon av RPE på en cellebærer i minigriser.

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Bioengineering utgave 189 Aldersrelatert makuladegenerasjon retinalpigmentert epitel RPE storøye dyremodell minigriser pars plana vitrektomi PPV cellebærer in vivo kirurgi preoperativ og postoperativ behandling
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