Brain Stem Transsection
Brain Stem Transsection - Related Videos
06:57
Spinal Cord Transection in the Larval Zebrafish
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Cited by 22 •
2014
After spinal transection, adult zebrafish have functional recovery by six weeks post-injury. To take advantage of larval transparency and faster recovery, we present a method for transecting the larval spinal cord. After transection, we observe sensory recovery beginning at 2 days post-injury, and C-bend movement by 3 days post-injury.
08:22
Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
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Cited by 16 •
2013
We describe a highly reproducible method for the permanent occlusion of a rodent major cerebral blood vessel. This technique can be accomplished with very little peripheral damage, minimal blood loss, a high rate of long-term survival, and consistent infarct volume commensurate with the human clinical population.
04:35
Generating Brain Endothelial Cells from Induced Pluripotent Stem Cells
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2025
This video demonstrates a protocol to induce the differentiation of induced pluripotent stem cells into brain endothelial cells.
11:02
Methods for Experimental Manipulations after Optic Nerve Transection in the Mammalian CNS
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Cited by 10 •
2011
Optic Nerve transection is a widely used model of adult CNS injury. This model is ideal for performing a number of experimental manipulations that target the retina globally or directly target the injured neuronal population of retinal ganglion cells.
03:45
Right Hemihepatectomy by Suprahilar Intrahepatic Transection of the Right Hemipedicle using a Vascular Stapler
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Cited by 1 •
2010
This video describes a right hemihepatectomy with intrahepatic transection of the right hemipedicle leaving the hepatoduodenal ligament completely untouched.
FAQs
Effects vary with the segment selected because each level contains pathways and circuits connected with different functions. A cut can interrupt communication between the brain and spinal cord while leaving some structures above or below it intact. Comparing outcomes after transections at different levels allows investigators to associate particular brainstem regions with respiration, cardiovascular regulation, consciousness, posture, or motor control.
Ascending pathways carry signals toward the brain, whereas descending pathways transmit commands toward the spinal cord and lower neural systems. Dividing these routes reveals how information normally moves through the brainstem. Preserving selected structures above or below the cut helps distinguish effects caused by pathway interruption from functions supported by tissue that remains connected.
The method shows that vital functions and behavior depend on organized brainstem circuits rather than on a single undifferentiated region. Changes in respiration, cardiovascular regulation, consciousness, posture, or movement can be related to the segment affected. This makes transection useful for examining how the brainstem integrates signals and coordinates activity between higher centers and the spinal cord.
Investigators select a defined brainstem level according to the functional relationship they want to test. They then examine which responses change after communication through that level is interrupted, while considering structures that remain above or below the division. This design supports anatomical and functional comparisons across brainstem segments without treating the entire region as physiologically identical.
Researchers can compare the presence, loss, or alteration of essential functions and behaviors after selected neural connections are interrupted. These observations help map brainstem segments to respiration, cardiovascular control, consciousness, posture, and motor activity. The resulting functional associations contribute to experimental neurophysiology by linking observable outcomes with the organization of neural pathways and circuits.
Findings from brain stem transection research provide a framework for understanding what may occur when traumatic injury disrupts brainstem tissue or its connections. The functional associations can help explain neurological syndromes and the mechanisms behind loss of essential functions. In medicine, this context connects experimental studies of pathway organization with the consequences of severe brainstem damage.