Lad Occlusion
Lad Occlusion - Related Videos
07:17
Remotely Triggered LAD Occlusion Using a Balloon Catheter in Spontaneously Breathing Mice
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Cited by 1 •
2024
This article presents a unique closed-chest technique for inducing myocardial ischemia-reperfusion injury (IRI) in mice. The presented method allows mice to breathe spontaneously while remotely inducing myocardial ischemia. This provides access to the animal for studying the dynamic processes of ischemia and reperfusion in situ and in real-time via noninvasive imaging.
08:23
LAD-Ligation: A Murine Model of Myocardial Infarction
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Cited by 81 •
2009
This video demonstrates how to use a fast and reliable model to study pathobiological and pathophysiological processes of myocardial ischemia.
10:39
Murine Left Anterior Descending (LAD) Coronary Artery Ligation: An Improved and Simplified Model for Myocardial Infarction
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Cited by 52 •
2017
We provide a reliable method for left anterior descending artery (LAD) ligation in a mouse model. This method is comparatively less invasive than other methods, involving endotracheal intubation, a left-sided thoracotomy approach, and thoracentesis. This method can be used as a model for both acute and chronic myocardial infarction (MI).
08:22
Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
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Cited by 16 •
2013
We describe a highly reproducible method for the permanent occlusion of a rodent major cerebral blood vessel. This technique can be accomplished with very little peripheral damage, minimal blood loss, a high rate of long-term survival, and consistent infarct volume commensurate with the human clinical population.
08:30
Use of a Hanging Weight System for Coronary Artery Occlusion in Mice
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Cited by 21 •
2011
A murine model for myocardial ischemia and ischemic preconditioning is an important tool study cardioprotective mechanisms in vivo. Here, we report an easy applicable in situ model for cardiac IP using a hanging-weight system for coronary artery occlusion.
FAQs
The usual initiating event is rupture of an atherosclerotic plaque within the coronary artery. The disrupted plaque promotes thrombus formation, and the resulting obstruction sharply reduces blood flow and oxygen delivery to heart muscle. This sequence converts a chronic vessel-wall disease into an acute ischemic emergency, because oxygen deprivation can rapidly produce myocardial injury.
The LAD supplies the front of the heart and much of the interventricular septum, so its obstruction can affect a substantial region of myocardium rather than a small isolated area. If oxygen delivery remains impaired, the event may produce an anterior myocardial infarction. The extent of this threatened territory explains why preserving flow is clinically important.
Evaluation combines symptoms with electrocardiography, cardiac biomarker testing, and coronary angiography. These approaches provide complementary evidence during assessment. Symptoms raise concern, electrocardiography and biomarkers contribute clinical information, and angiography helps assess the coronary circulation. Used together, they help clinicians identify an occlusion and guide urgent decisions about restoring blood flow.
Rapid restoration of blood flow is important because it can limit myocardial injury before oxygen deprivation causes more extensive damage. In the setting of LAD occlusion, timely reperfusion may preserve cardiac function and improve survival. This time-sensitive relationship makes early recognition more than a diagnostic goal; it directly affects the potential outcome of the acute event.
Percutaneous coronary intervention is a common way to restore blood flow after an occlusion is identified. By reopening the affected coronary passage, the procedure aims to re-establish oxygen delivery to threatened myocardium. Its clinical value is measured not only by treating the blockage, but also by limiting myocardial injury, preserving cardiac function, and improving survival.
It combines an acute vascular event with a potentially large area of threatened heart muscle and a treatment window in which rapid action matters. Emergency clinicians therefore emphasize early recognition through symptoms, electrocardiography, cardiac biomarkers, and coronary angiography, followed by prompt restoration of flow. The objective is to reduce myocardial injury while maintaining cardiac function and improving survival.