Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging

Filip Niemann; Alireza Shahbabaie; Sven Pa&#223;mann; Steffen Riemann; Robert Malinowski; Harun Kocata&#351;; Leonardo M. Caisachana Guevara; Mohamed Abdelmotaleb; Daria Antonenko; Felix Blankenburg; Rico Fischer; Gesa Hartwigsen; Shu-Chen Li; Michael A. Nitsche; Axel Thielscher; Dagmar Timmann; Anna Fromm; Dayana Hayek; Ann-Kathrin Hubert; Andrew K. Martin; Alexander Hunold; Agnes Fl&#246;el; Marcus Meinzer

doi:10.3791/67155

גירוי זרם ישיר טרנס-גולגולתי ממוקד ממוקד הניתן במהלך הדמיית תהודה מגנטית תפקודית

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JoVE Journal Neuroscience

Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging

גירוי זרם ישיר טרנס-גולגולתי ממוקד ממוקד הניתן במהלך הדמיית תהודה מגנטית תפקודית

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09:33 min

November 15, 2024

DOI: 10.3791/67155-v

Filip Niemann*¹, Alireza Shahbabaie*¹, Sven Paßmann¹, Steffen Riemann¹, Robert Malinowski¹, Harun Kocataş¹, Leonardo M. Caisachana Guevara^1,2, Mohamed Abdelmotaleb¹, Daria Antonenko¹, Felix Blankenburg^3,4, Rico Fischer², Gesa Hartwigsen^5,6, Shu-Chen Li^7,8, Michael A. Nitsche^9,10,11, Axel Thielscher^12,13, Dagmar Timmann¹⁴, Anna Fromm¹, Dayana Hayek¹, Ann-Kathrin Hubert¹, Andrew K. Martin^15,16, Alexander Hunold¹⁷, Agnes Flöel*^1,18, Marcus Meinzer*¹

¹Department of Neurology,University Medicine Greifswald, ²Department of Psychology,University Medicine Greifswald, ³Berlin School of Mind and Brain,Humboldt Universität zu Berlin, ⁴Neurocomputation and Neuroimaging Unit,Freie Universität Berlin, ⁵Wilhelm-Wundt-Institute for Psychology, Cognitive and Biological Psychology,Leipzig University, ⁶Lise Meitner Research Group Cognition and Plasticity,Max Planck Institute for Human Cognitive and Brain Sciences, ⁷Lifespan Developmental Neuroscience, Faculty of Psychology,Technische Universität Dresden, ⁸Centre for Tactile Internet with Human-in-the-Loop,Technische Universität Dresden, ⁹Department of Psychology and Neurosciences,Leibniz Research Centre for Working Environment and Human Factors, ¹⁰German Centre for Mental Health (DZPG), ¹¹Clinic of Psychiatry and Psychotherapy, Protestant Hospital of Bethel Foundation, University Hospital OWL,Bielefeld University, ¹²Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research,Copenhagen University Hospital Amager and Hvidovre, ¹³Department of Health Technology,Technical University of Denmark, ¹⁴Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS),Essen University Hospital, ¹⁵Department of Psychology,University of Kent, ¹⁶Kent Medway Medical School, ¹⁷Institute of Biomedical Engineering and Informatics,Technische Universität Ilmenau, ¹⁸German Center for Neurodegenerative Diseases (DZNE Site Greifswald)

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Overview

This study presents a method for neuronavigated electrode placement for focal transcranial direct current stimulation (tDCS) during functional magnetic resonance imaging (fMRI). The goal is to enhance electrode placement accuracy and consequently improve the stimulation's behavioral and neural effects.

Key Study Components

Area of Science

Neuroscience
Neurostimulation
Imaging Techniques

Background

tDCS is used to modulate brain functions, yet accurate electrode placement is a significant challenge.
Existing placement methods may not optimize current delivery effectiveness.
Neuronavigated placement is proposed to enhance electrode positioning relative to individual anatomy.
This method involves optimizing positions based on realistic current flow simulations.

Purpose of Study

To compare the accuracy of neuronavigated tDCS electrode placement versus traditional methods.
To determine if increased accuracy leads to improvements in stimulation effects during fMRI.
To ultimately enhance our understanding of tDCS effects on brain function in health and disease.

Methods Used

Functional magnetic resonance imaging (fMRI) along with tDCS for stimulating specific brain regions.
The method focuses on precise electrode positioning for targeted regions, like the dorsal lateral prefrontal cortex.
Included meticulous steps for preparation, configuration, and participant positioning within the MRI environment.
Verification techniques for validation of electrode placement through neuronavigation software.

Main Results

The protocol aims to maximize the effects of tDCS through improved electrode accuracy for each participant.
The anticipated findings include enhanced behavioral and neural responses resulting from optimized tDCS application.
Positive implications for future research on tDCS mechanisms in various brain functions.

Conclusions

This study demonstrates how neuronavigated electrode placement can significantly enhance the precision of tDCS.
Future research may expand our understanding of tDCS effects on brain plasticity and functionality.
Improvements in methodology position researchers to address brain function modulation more effectively.

Frequently Asked Questions

What are the advantages of neuronavigated electrode placement?

Neuronavigated placement allows for individualized optimization based on anatomy, enhancing placement accuracy and stimulation effectiveness.

How is the primary biological model prepared for the study?

Participants are positioned to allow for accurate electrode placement while ensuring comfort and minimizing displacement during fMRI.

What types of data or outcomes are expected from this method?

The study aims to generate data on the accuracy of electrode placement and subsequent behavioral and neural responses to the stimulation.

How can this method be adapted for different research questions?

The neuronavigated approach can be customized for various brain regions and stimulation parameters to suit specific research purposes.

What are the key limitations of this protocol?

Potential limitations include participant variability and the complexity of accurately configuring the neuronavigation software and hardware.

What future applications may arise from this research?

Future studies could explore new mechanisms of brain function enhancement using tDCS and broaden its applications for various neurological conditions.

פרוטוקול זה מתאר את השיטה של מיקום אלקטרודות נוירו-ניווטיות עבור גירוי זרם ישיר טרנס-גולגולתי (tDCS) הניתן במהלך דימות תהודה מגנטית תפקודי (fMRI).

אנו מתארים שיטה חדשה של מיקום אלקטרודות נוירונוויטציה עבור tDCS מוקדי המתחשבות באנטומיית הראש של משתתף בודד. אנו רוצים להבין אם מיקום מנווט עצבי של אלקטרודות tDCS מביא לדיוק מיקום מעולה בהשוואה לשיטות מיקום מסורתיות, והאם דיוק מעולה זה משפר את ההשפעה ההתנהגותית והעצבית של הגירוי. אחד האתגרים הגדולים ביותר בניסוי tDCS הוא להבטיח מיקום מדויק של אלקטרודות על הקרקפת של כל משתתף במחקר באופן שהאספקה הנוכחית היא היעילה ביותר.

לכן, על החוקרים להבטיח מיקום מדויק של אלקטרודות ולאמת תזוזה אפשרית. במהלך fMRI. ראשית, הגישה שלנו מייעלת את מיקומי האלקטרודות על הקרקפת באמצעות סימולציות זרם מציאותיות של זרימת זרם עבור כל משתתף במחקר.

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