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Advanced Biology

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Genetics

DNA Methylation and Gene Silencing

Description

DNA methylation is a DNA change that can help turn genes on or off. It happens most often at CpG dinucleotides, which are places where a cytosine is followed by a guanine in the DNA sequence. Methyl groups added at these sites may affect gene expression and are often studied near promoters and other gene control regions.

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Transcript

La metilazione del DNA è una modificazione chimica del DNA che influenza l'espressione genica in diversi contesti cellulari. Molti ricercatori sono interessati al meccanismo e alle funzioni di questo processo, poiché l'aberrante metilazione del DNA è stata associata a malattie come il cancro.

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