This is a free preview. For full access
Genetics
Mapping DNA With Histone Marks
Description
Histones help package DNA in eukaryotic nuclei. DNA wraps around these proteins to form chromatin, the compact structure that organizes the genome. Histones can also carry chemical changes, and those changes can affect gene expression.
Scientists use chromatin immunoprecipitation, or ChIP, to fin...
Show More
Transcript
Chromatin immunoprecipitation, or “ChIP,” is a technique used by researchers to assess protein-DNA interactions. Protein factors play important roles in the gene regulation; not only do they organize DNA in chromosomes, but they also bind to specific DNA sequences—called regulatory sites—to activate or repress expression. Duri...
Show More