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Genetics
Using Microarrays to Compare Gene Expression
Description
Microarrays let scientists compare gene expression by measuring how strongly genes are turned on in a sample. They rely on complementary binding, which means matching nucleic acid strands stick to each other. In this method, probes attached to a glass chip bind to nucleic acids taken from samples.
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Transcript
DNA microarrays are widely used tools to simultaneously measure the expression of many different genes. They consist of thousands of probes—each representing a different gene—immobilized on “chips” or slides, and rely on complementary hybridization to evaluate gene expression in different biological conditions.
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