Middle Cerebral Artery Doppler

Middle cerebral artery (MCA) Doppler is a noninvasive ultrasound technique that measures blood-flow velocity in the brain’s major lateral cerebral artery, helping assess cerebral circulation. During transcranial or fetal ultrasound, the probe directs sound waves toward the MCA; moving red blood cells shift the reflected frequency, allowing calculation of velocity and waveform indices such as pulsatility and resistance. In biology and clinical research, MCA Doppler supports evaluation of cerebrovascular hemodynamics, detection of altered perfusion, and monitoring of conditions such as vasospasm or fetal anemia, linking vascular function to physiological and pathological states.

Middle Cerebral Artery Doppler - Related Videos

Research

JoVE Journal - Medicine

Utilizing a Cranial Window to Visualize the Middle Cerebral Artery During Endothelin-1 Induced Middle Cerebral Artery Occlusion

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Cited by 4 •

2013

This article describes a method for visualizing rat cerebral arteries through a cranial window using temporal craniectomy in order to view proximal portions of the middle cerebral artery (Figure 1). This versatile method can be combined with various techniques of drug delivery to measure cerebral artery reactivity in vivo.

Endothelin-1 Induced Middle Cerebral Artery Occlusion Model for Ischemic Stroke with Laser Doppler Flowmetry Guidance in Rat

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Cited by 26 •

2013

Several animal models of cerebral ischemia have been developed to simulate the human condition of stroke. This protocol describes the endothelin-1 (ET-1) induced middle cerebral artery occlusion (MCAO) model for ischemic stroke in rats. In addition, important considerations, advantages, and shortcomings of this model are discussed.

Intraluminal Middle Cerebral Artery Occlusion (MCAO) Model for Ischemic Stroke with Laser Doppler Flowmetry Guidance in Mice

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Cited by 76 •

2011

The intraluminal middle cerebral artery occlusion (MCAO) model is the most frequent used model among experimental ischemic stroke models. Here we will demonstrate the entire model in detail with the guide of Laser Doppler flowmetry, and its representative results.

Positioning Laser Doppler Probe: A Technique to Implant Probe Over Middle Cerebral Artery for Blood Flow Measurement in Murine Model

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2025

This video describes the surgical procedure to immobilize the laser Doppler probe over the murine brain's middle cerebral artery, or MCA. The probe helps to measure the blood flow in the brain's microvasculature by measuring the Doppler shift caused due to the motion of red blood cells within the artery.

Research

JoVE Journal - Medicine
Free Sample

Optimized System for Cerebral Perfusion Monitoring in the Rat Stroke Model of Intraluminal Middle Cerebral Artery Occlusion

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Cited by 8 •

2013

Cerebral perfusion monitoring has been demonstrated to improve accuracy in ischemic stroke models. Technical difficulties often limit the use of this essential tool for cerebrovascular research. In this video, an optimized system is shown to obtain a single or multi-site hemodynamic monitoring during intraluminal middle cerebral artery occlusion in rats.

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