Utilizing a Cranial Window to Visualize the Middle Cerebral Artery During Endothelin-1 Induced Middle Cerebral Artery Occlusion

Robert W. Regenhardt; Saeed Ansari; Hassan Azari; Kenneth J. Caldwell; Adam P. Mecca

doi:10.3791/50015

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Utilizing a Cranial Window to Visualize the Middle Cerebral Artery During Endothelin-1 Induced Middle Cerebral Artery Occlusion

JoVE Journal
Medicine
Author Produced

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JoVE Journal Medicine

Utilizing a Cranial Window to Visualize the Middle Cerebral Artery During Endothelin-1 Induced Middle Cerebral Artery Occlusion

14,874 Views

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07:43 min

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February 22, 2013

DOI:

10.3791/50015-v

DOI:

10.3791/50015-v

•

07:43 min

February 22, 2013

•

7 Views

Robert W. Regenhardt¹, Saeed Ansari², Hassan Azari³, Kenneth J. Caldwell², Adam P. Mecca¹

¹Department of Physiology and Functional Genomics,University of Florida , ²Department of Neurosurgery, McKnight Brain Institute,University of Florida , ³Department of Anatomical Sciences,Shiraz University of Medical Sciences, Shiraz, Iran

Summary

This article describes a method for visualizing rat cerebral arteries through a cranial window using temporal craniectomy in order to view proximal portions of the middle cerebral artery (Figure 1). This versatile method can be combined with various techniques of drug delivery to measure cerebral artery reactivity in vivo.