Lidocaine Injection
Lidocaine Injection - Related Videos
08:30
Intra-articular Shoulder Injection for Reduction Following Shoulder Dislocation
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2023
Source: Rachel Liu, BAO, MBBCh, Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA The anterior shoulder dislocation is one of the most common joint dislocations seen in emergency settings. In anterior shoulder dislocation, the humeral head is displaced out of the glenohumeral joint in front of the scapular glenoid, resulting in a loss of the articulation between the arm and the rest of the shoulder. This can be caused by a fall onto an abducted, extended, and externally...
04:17
Stereotaxic Viral Injection for Targeted Neuronal Gene Editing in the Mouse Brain
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2025
Source: Fricano-Kugler, C. J., et al. Designing, Packaging, and Delivery of High Titer CRISPR Retro and Lentiviruses via Stereotaxic Injection. J. Vis. Exp. (2016)This video demonstrates stereotaxic viral injection for precise neuronal gene editing in the mouse brain. The protocol ensures accurate virus delivery to the dentate gyrus, enabling fluorescent labeling and CRISPR-mediated gene knockout to study neural circuits, gene function, and disease mechanisms in vivo.
11:28
Designing, Packaging, and Delivery of High Titer CRISPR Retro and Lentiviruses via Stereotaxic Injection
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Cited by 25 •
2016
The CRISPR/Cas9 system offers the potential to make targeted genome editing accessible and affordable to the scientific community. This protocol is intended to demonstrate how to create viruses that will knockout a gene of interest using the CRISPR/Cas9 system, and then inject them stereotaxically into the adult mouse brain.
07:34
Minimally-invasive Technique for Injection into Rat Optic Nerve
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Cited by 4 •
2015
Direct injection into the rat optic nerve is useful for regenerative research. We demonstrate a minimally-invasive technique for direct injection into a rat optic nerve that does not involve opening the skull. Using this method, surgical complications are minimized and recovery is more rapid.
14:06
Preparation of an Awake Mouse for Recording Neural Responses and Injecting Tracers
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Cited by 26 •
2012
Electrophysiological characterization of neuronal responses is important for understanding brain function and for guiding the placement of dyes for pathway tracing. However, many studies are performed in anesthetized animals. To understand brain function without anesthetics, we developed a method to record neuronal response properties and inject dyes in awake mouse.
FAQs
After diffusing into excitable tissue, lidocaine blocks voltage-gated sodium channels in sensory nerves. This prevents the inward movement of sodium ions needed to initiate and propagate action potentials. Without those electrical signals traveling along the nerve, sensory information from the treated area does not reach the central nervous system normally, producing temporary loss of sensation during the procedure.
The two approaches deliver lidocaine to different anatomical targets. Local infiltration places the medication at the area being treated, whereas a nerve block targets a nerve pathway serving a region. Clinicians select between them according to the injection site and the area requiring temporary sensory loss, allowing lidocaine injection to support both localized and regionally distributed procedural anesthesia.
These considerations guide how clinicians plan lidocaine injection for an individual procedure. The selected dose and injection site must match the intended anesthetic effect, while patient factors may affect the suitability of the intervention. Considering all three helps clinicians use the medication in a way that supports temporary, reversible sensory loss for the specific clinical situation.
Lidocaine injection is useful when clinicians need rapid, temporary interruption of sensation during a procedure. Its reversible effect allows sensation to return after the intervention, while the choice of local infiltration or nerve block adapts administration to the treatment area. These characteristics make it relevant to wound repair, minor surgery, and dental treatment.
Common procedural applications include wound repair, minor surgery, and dental treatment. In these settings, clinicians administer lidocaine through local infiltration or a nerve block, depending on the treatment site and desired region of sensory loss. The medication’s rapid onset supports timely procedural anesthesia, while its temporary action limits the effect to the period in which anesthesia is needed.
Beyond procedural anesthesia, lidocaine injection has a role in selected emergency cardiovascular care for certain ventricular cardiac arrhythmias. This application depends on the clinical context rather than the need to numb a procedural site. Its relevance reflects lidocaine’s activity in excitable tissue, extending its use from sensory nerve signaling to specific cardiac rhythm management situations.