Ductal Structure Visualization

Ductal structure visualization is the imaging-based depiction of ducts and their branching anatomy, helping clinicians assess fluid-conducting pathways that may be difficult to examine directly. Depending on the method, imaging traces natural duct contents or uses a contrast medium introduced into a duct, allowing differences in anatomy and signal or density to outline the lumen, narrowing, dilation, and blockage. In medicine, these examinations support evaluation of biliary, pancreatic, mammary, salivary, and other ductal systems, contributing to diagnosis, procedural planning, and treatment monitoring. Clear visualization can also improve understanding of disease patterns and guide targeted intervention.

Ductal Structure Visualization - Related Videos

Research

JoVE EoE - Pancreatic Cancer

Acinar-to-Ductal Metaplasia Induction: A Method to Study Acinar Cell to Ductal Cell Differentiation in 3D Ex Vivo Culture

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2023

This video describes the technique of differentiating pancreatic acinar cells to ductal cells in ex vivo 3D culture. This helps to understand the mechanisms regulating the acinar-to-ductal metaplasia (ADM), a key process in the early development of pancreatic cancer.

Ultrasound-Guided Implantation: A Technique to Implant Pancreatic Ductal Adenocarcinoma Cells into an Adult Mouse

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2023

This video describes the protocol for ultrasound-guided orthotopic implantation of murine-derived pancreatic ductal adenocarcinoma cells directly into the pancreas of the mouse. This causes less inflammation at the implantation site compared to surgical procedures.

Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency

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2024

The present protocol describes the reprogramming of Pancreatic Ductal Adenocarcinoma (PDAC) and normal pancreatic ductal epithelial cells into induced pluripotent stem cells (iPSCs). We provide an optimized and detailed, step-by-step procedure, from preparing lentivirus to establishing stable iPSC lines.

Research

JoVE Journal - Medicine
Free Sample

Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer

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Cited by 27 •

2014

Activation of latent mutations with adenovirus-Cre into the mammary ductal system results in a clinically relevant metastatic breast cancer. Incorporation of a YFP promoter allows tracking of distal metastatic tumor cells. This model is useful to study latent metastasis, anti-tumor immunity, and for designing novel immunotherapies to treat breast cancer.

Using High Resolution Computed Tomography to Visualize the Three Dimensional Structure and Function of Plant Vasculature

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Cited by 62 •

2013

High resolution x-ray computed tomography (HRCT) is a non-destructive diagnostic imaging technique that can be used to study the structure and function of plant vasculature in 3D. We demonstrate how HRCT facilitates exploration of xylem networks across a wide range of plant tissues and species.

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