High-density Electrodes

High-density electrodes are electrode arrays with many closely spaced recording or stimulation sites, enabling detailed measurement and control of electrical activity in biological tissue. Each contact detects local voltage changes or delivers electrical current, while the array’s small spacing samples activity across neighboring cells or tissue regions with greater spatial resolution than widely spaced electrodes. In medicine, these devices support neural recording, brain mapping, seizure localization, neuromodulation, and brain-computer interface research. Their ability to capture fine electrical patterns can improve understanding of nervous-system function and help guide more precise diagnosis, stimulation therapies, and development of assistive technologies.

High-density Electrodes - Related Videos

Research

JoVE Journal - Neuroscience

Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications

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Cited by 24 •

2016

This article provides a detailed description on the fabrication process of a high contact-density flat interface nerve electrode (FINE). This electrode is optimized for recording and stimulating neural activity selectively within peripheral nerves.

Education

JoVE Core - Chemistry

Standard Electrode Potentials

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2020

On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...

Fabrication of Amperometric Electrodes

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Cited by 8 •

2009

This protocol describes how to generate carbon fiber electrodes. The electrodes are subsequently used to detect catecholamine release from vesicles with carbon fiber amperometry.

Density Gradient Ultracentrifugation

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2023

Density gradient ultracentrifugation is a common technique used to isolate and purify biomolecules and cell structures. This technique exploits the fact that, in suspension, particles that are more dense than the solvent will sediment, while those that are less dense will float. A high-speed ultracentrifuge is used to accelerate this process in order to separate biomolecules within a density gradient, which can be established by layering liquids of decreasing density in a centrifuge tube. The...

Generating an Ultra-Low-Density Neuronal Culture Using a High-Density Neuronal Feeder Layer

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2025

This video demonstrates the method for culturing ultra-low-density neurons in the presence of a high-density neuronal feeder layer. It establishes a co-culture of varying-density neurons, ensuring close physical proximity. The growth factors secreted by high-density neurons help neuronal survival and growth, maintaining ultra-low-density neurons for a longer time period.

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