Spinal Cord Compression

Spinal cord compression is a medical condition in which pressure on the spinal cord or its surrounding nerve roots disrupts communication between the brain and body, making prompt recognition important. Tumors, herniated discs, fractures, infection, or degenerative changes can narrow the spinal canal and compress neural tissue, impairing nerve signaling and sometimes blood flow. Symptoms may include back or neck pain, weakness, numbness, altered reflexes, and loss of bladder or bowel control. In medicine, neurological examination and magnetic resonance imaging help identify the cause and severity, while treatment may involve corticosteroids, surgery, radiation, or other measures to relieve pressure and prevent permanent disability.

Spinal Cord Compression - Related Videos

Research

JoVE Journal - Medicine
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Calibrated Forceps Model of Spinal Cord Compression Injury

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Cited by 57 •

2015

Spinal cord injury models should be highly reproducible. We demonstrate that the calibrated forceps compression model of spinal cord injury is an easy to use surgical method for generating reproducible injuries to the murine spinal cord.

Research

JoVE Journal - Medicine
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A Neonatal Mouse Spinal Cord Compression Injury Model

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Cited by 4 •

2016

This article describes a method for generating a reproducible spinal cord compression injury (SCI) in the neonatal mouse. The model provides an advantageous platform for studying mechanisms of adaptive plasticity that underlie spontaneous functional recovery.

Research

JoVE EoE - Neuroimaging

Assessing Spinal Cord Compression Using Diffusion Tensor Imaging

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2025

Source: Zheng, W. et. al., Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression. J. Vis. Exp. (2019)This video demonstrates diffusion tensor imaging in assessing chronic spinal cord compression. By analyzing water diffusion patterns, fractional anisotropy, and apparent diffusion coefficient values, the findings reveal axonal damage in compressed regions. The findings provide critical insights into spinal cord pathology and structural integrity.

Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats

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Cited by 55 •

2012

We describe two tactile sensory testing methods for acute or chronic periods of spinal cord injury in rats. These validated procedures can detect the development and maintenance of allodynia-like sensations.

Inducing a Spinal Cord Contusion in a Mouse Model Using a Spinal Cord Injury Coaxial Platform

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2025

Source: Elzat, E. Y. Y., et al., Establishing a Mouse Contusion Spinal Cord Injury Model Based on a Minimally Invasive Technique. J. Vis. Exp. (2022).This video demonstrates the method for inducing a contusion injury at the T9 level spinal cord in a mouse model, using a spinal cord injury coaxial platform. A weight is dropped on the T9 level spinal cord that creates a contusion that immediately causes tissue discoloration and swelling.

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