Brain Location Control
Brain Location Control - Related Videos
05:12
A Micro-CT-based Method for Characterizing Lesions and Locating Electrodes in Small Animal Brains
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Cited by 8 •
2018
This article describes a straightforward method to prepare small animal brains for micro-CT imaging, in which lesions can be quantified and electrodes located with high precision in the context of the whole brain.
05:30
Controlled Cortical Impact Model for Traumatic Brain Injury
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Cited by 87 •
2014
Traumatic brain injuries (TBIs) remain a serious health problem. Using the controlled cortical impact surgery model, research on the effects of TBI and possible treatment methods may be performed.
11:12
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
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Cited by 27 •
2014
Adaptive deep brain stimulation (aDBS) is effective for Parkinson’s disease, improving symptoms and reducing power consumption compared to conventional deep brain stimulation (cDBS). In aDBS we track a local field potential biomarker (beta oscillatory amplitude) in real time and use this to control the timing of stimulation.
01:13
Location and Orientation of the Heart
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2024
The human heart, despite its modest size and weight, is an organ of remarkable strength and endurance. Roughly the size of a fist, the heart weighs between 250 and 350 grams and is nestled within the mediastinum, the medial cavity of the thorax. It extends obliquely for about 12 to 14 cm, resting on the superior surface of the diaphragm. The heart is positioned anterior to the vertebral column and posterior to the sternum, with two-thirds of its mass lying to the left of the midsternal line.
08:58
A Benchtop Approach to the Location Specific Blood Brain Barrier Opening using Focused Ultrasound in a Rat Model
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Cited by 6 •
2020
Focused ultrasound with microbubble agents can open the blood brain barrier focally and transiently. This technique has been used to deliver a wide range of agents across the blood brain barrier. This article provides a detailed protocol for the localized delivery to the rodent brain with or without MRI guidance.
FAQs
Landmarks and imaging provide the reference system for establishing anatomical coordinates before a target is selected. This spatial framework helps researchers align an intended site with the relevant brain region rather than relying only on approximate position. More precise localization strengthens comparisons across experiments and helps separate effects produced by neighboring structures.
Anatomical verification confirms whether an electrode, tracer injection, lesion, or stimulation site reached the intended location. Without this check, observed effects could be attributed to the wrong structure or to an adjacent region. Verification therefore supports more defensible links between the targeted anatomy, neural activity, and measured behavioral or physiological outcomes.
Spatial precision allows researchers to associate a manipulation or recording with a defined neural circuit instead of treating a broad area as functionally uniform. This distinction matters when nearby structures contribute different functions. By controlling location, investigators can better evaluate whether local activity or disruption is related to a particular behavior or physiological process.
A typical workflow establishes anatomical coordinates from landmarks and imaging, selects the intended brain site, and places the chosen instrument or intervention at that location. Researchers then verify the anatomy after recording, injection, lesion, or stimulation. These steps create a traceable connection between the experimental manipulation and the brain region under study.
Electrodes can be placed at selected sites to examine local neural activity, while injected tracers support circuit mapping by marking anatomically connected pathways. Stimulation delivers an intervention to a defined location, allowing researchers to examine its functional consequences. Choosing among these approaches depends on whether the study emphasizes activity, connectivity, or targeted modulation.
Precise localization supports lesion studies, electrophysiology, circuit mapping, and targeted neuromodulation. In lesion experiments, it helps relate disrupted anatomy to resulting changes; in electrophysiology, it identifies the source region of recorded activity. The same control improves interpretation of circuit organization and supports research into brain dysfunction by linking effects to defined neural sites.