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A Benchtop Approach to the Location Specific Blood Brain Barrier Opening using Focused Ultrasound in a Rat Model
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
A Benchtop Approach to the Location Specific Blood Brain Barrier Opening using Focused Ultrasound in a Rat Model
DOI:

08:58 min

June 13, 2020

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Chapters

  • 00:05Introduction
  • 00:32Intracranial Targeting Procedure
  • 03:26Focused Ultrasound Procedure
  • 07:12Results: Focused Ultrasound BBB Opening
  • 08:43Conclusion

Summary

Automatic Translation

Focused ultrasound with microbubble agents can open the blood brain barrier focally and transiently. This technique has been used to deliver a wide range of agents across the blood brain barrier. This article provides a detailed protocol for the localized delivery to the rodent brain with or without MRI guidance.

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