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A Benchtop Approach to the Location Specific Blood Brain Barrier Opening using Focused Ultrasound in a Rat Model
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Neuroscience
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JoVE Journal Neuroscience
A Benchtop Approach to the Location Specific Blood Brain Barrier Opening using Focused Ultrasound in a Rat Model

A Benchtop Approach to the Location Specific Blood Brain Barrier Opening using Focused Ultrasound in a Rat Model

DOI:
10.3791/61113-v

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08:58 min

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June 13, 2020

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, , ,
1Department of Radiology,University of Alabama at Birmingham, 2Department of Neurobiology,University of Alabama at Birmingham

Chapters

  • 00:05Introduction
  • 00:32Intracranial Targeting Procedure
  • 03:26Focused Ultrasound Procedure
  • 07:12Results: Focused Ultrasound BBB Opening
  • 08:43Conclusion

Summary

Automatic Translation

Automatic Translation

Focused ultrasound with microbubble agents can open the blood brain barrier focally and transiently. This technique has been used to deliver a wide range of agents across the blood brain barrier. This article provides a detailed protocol for the localized delivery to the rodent brain with or without MRI guidance.

Tags

Focused UltrasoundBlood-brain BarrierRat ModelMicro-bubblesMRIStereotaxic FrameBrain RegionAnesthesiaCatheterTail Vein

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