Morris Water Maze Test: Optimization for Mouse Strain and Testing Environment

Daniel S. Weitzner; Elizabeth B. Engler-Chiurazzi; Linda A. Kotilinek; Karen Hsiao Ashe; Miranda Nicole Reed

doi:10.3791/52706

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Morris water maze Test: Ottimizzazione per ceppo di topi e Ambiente di prova

Morris Water Maze Test: Optimization for Mouse Strain and Testing Environment

JoVE Journal
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Morris Water Maze Test: Optimization for Mouse Strain and Testing Environment

Morris water maze Test: Ottimizzazione per ceppo di topi e Ambiente di prova

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21,452 Views

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10:24 min

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June 22, 2015

DOI:

10.3791/52706-v

DOI:

10.3791/52706-v

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10:24 min

June 22, 2015

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13 Views

Daniel S. Weitzner¹, Elizabeth B. Engler-Chiurazzi², Linda A. Kotilinek³, Karen Hsiao Ashe^3,4,5, Miranda Nicole Reed^1,6

¹Department of Psychology, Behavioral Neuroscience,West Virginia University, ²Department of Physiology and Pharmacology,West Virginia University, ³Department of Neurology,N. Bud Grossman Center for Memory Research and Care, University of Minnesota, ⁴Department of Neuroscience,N. Bud Grossman Center for Memory Research and Care, University of Minnesota, ⁵GRECC, VA Medical Center, ⁶Center for Neuroscience, Center for Basic and Translational Stroke Research,West Virginia University

Summary

This manuscript describes a Morris water maze (MWM) protocol tailored for use with a commonly used mouse model of Alzheimer's disease. The MWM is widely used in transgenic mouse models. Implementation of a procedure sensitive to the background strain of the mouse model is essential for detecting group differences.